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P63783 (CLPP2_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit 2
EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp 2
Gene names
Name:clpP2
Ordered Locus Names:Rv2460c, MT2535
ORF Names:MTV008.16c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444

Subcellular location

Cytoplasm By similarity HAMAP MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgrowth

Inferred from mutant phenotype. Source: MTBBASE

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: MTBBASE

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214ATP-dependent Clp protease proteolytic subunit 2 HAMAP MF_00444
PRO_0000179597

Sites

Active site1101 By similarity
Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
P63783 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4B26A854F0F984AB

FASTA21423,540
        10         20         30         40         50         60 
MNSQNSQIQP QARYILPSFI EHSSFGVKES NPYNKLFEER IIFLGVQVDD ASANDIMAQL 

        70         80         90        100        110        120 
LVLESLDPDR DITMYINSPG GGFTSLMAIY DTMQYVRADI QTVCLGQAAS AAAVLLAAGT 

       130        140        150        160        170        180 
PGKRMALPNA RVLIHQPSLS GVIQGQFSDL EIQAAEIERM RTLMETTLAR HTGKDAGVIR 

       190        200        210 
KDTDRDKILT AEEAKDYGII DTVLEYRKLS AQTA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAA16037.1.
AE000516 Genomic DNA. Translation: AAK46835.1.
PIRC70865.
RefSeqNP_216976.1. NC_000962.2.
NP_337021.1. NC_002755.2.

3D structure databases

ProteinModelPortalP63783.
ModBaseSearch...

Protein-protein interaction databases

IntActP63783. 1 interaction.

Protein family/group databases

MEROPSS14.009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002187; EBMYCP00000002187; EBMYCG00000002185.
EBMYCT00000071970; EBMYCP00000070029; EBMYCG00000071965.
GeneID888174.
925797.
GenomeReviewsGene locus MT2535 in contig AE000516_GR.
Gene locus Rv2460c in contig AL123456_GR.
KEGGmtc:MT2535.
mtu:Rv2460c.
PATRIC18127328. VBIMycTub22151_2772.
TIGRMT2535.

Organism-specific databases

TubercuListRv2460c.

Phylogenomic databases

GeneTreeEBGT00050000015874.
HOGENOMHBG558421.
OMAQDPYTKL.
PhylomeDBP63783.
ProtClustDBPRK12553.

Enzyme and pathway databases

BRENDA3.4.21.92. 3445.

Family and domain databases

HAMAPMF_00444. ClpP.
[Tree]
InterProIPR023562. Pept_S14/S49.
IPR001907. Pept_S14_ClpP.
IPR018215. Pept_S14_ClpP_AS.
[Graphical view]
KOK01358.
PANTHERPTHR10381. Pept_S14_ClpP. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP2_MYCTU
AccessionPrimary (citable) accession number: P63783
Secondary accession number(s): O53187
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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