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P63778

- CISY2_MYCBO

UniProt

P63778 - CISY2_MYCBO

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Protein
Putative citrate synthase 2
Gene
citA, Mb0913c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei250 – 2501 By similarity
Active sitei303 – 3031 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative citrate synthase 2 (EC:2.3.3.16)
Gene namesi
Name:citA
Ordered Locus Names:Mb0913c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Putative citrate synthase 2
PRO_0000169950Add
BLAST

Proteomic databases

PRIDEiP63778.

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb0913c.

Structurei

3D structure databases

ProteinModelPortaliP63778.
SMRiP63778. Positions 11-357.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021225.
KOiK01647.
OMAiTITERFM.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 2 hits.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63778-1 [UniParc]FASTAAdd to Basket

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MTVVPENFVP GLDGVVAFTT EIAEPDKDGG ALRYRGVDIE DLVSQRVTFG    50
DVWALLVDGN FGSGLPPAEP FPLPIHSGDV RVDVQAGLAM LAPIWGYAPL 100
LDIDDATARQ QLARASVMAL SYVAQSARGI YQPAVPQRII DECSTVTARF 150
MTRWQGEPDP RHIEAIDAYW VSAAEHGMNA STFTARVIAS TGADVAAALS 200
GAIGAMSGPL HGGAPARVLP MLDEVERAGD ARSVVKGILD RGEKLMGFGH 250
RVYRAEDPRA RVLRAAAERL GAPRYEVAVA VEQAALSELR ERRPDRAIET 300
NVEFWAAVVL DFARVPANMM PAMFTCGRTA GWCAHILEQK RLGKLVRPSA 350
IYVGPGPRSP ESVDGWERVL TTA 373
Length:373
Mass (Da):40,147
Last modified:October 11, 2004 - v1
Checksum:iAABF5238CB79B54D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42157.1.
RefSeqiNP_854570.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD93774; CAD93774; Mb0913c.
GeneIDi1092810.
KEGGimbo:Mb0913c.
PATRICi18003672. VBIMycBov88188_0994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42157.1 .
RefSeqi NP_854570.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63778.
SMRi P63778. Positions 11-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb0913c.

Proteomic databases

PRIDEi P63778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD93774 ; CAD93774 ; Mb0913c .
GeneIDi 1092810.
KEGGi mbo:Mb0913c.
PATRICi 18003672. VBIMycBov88188_0994.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021225.
KOi K01647.
OMAi TITERFM.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 2 hits.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiCISY2_MYCBO
AccessioniPrimary (citable) accession number: P63778
Secondary accession number(s): Q10529, X2BG39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism By similarity.

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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