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Protein

Putative citrate synthase 2

Gene

citA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.By similarity

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative citrate synthase 2 (citA), Citrate synthase (gltA2)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei250PROSITE-ProRule annotation1
Active sitei303PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Transferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-932-MONOMER
UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Putative citrate synthase 2 (EC:2.3.3.16)
Gene namesi
Name:citA
Ordered Locus Names:BQ2027_MB0913C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001699501 – 373Putative citrate synthase 2Add BLAST373

Proteomic databases

PRIDEiP63778

Structurei

3D structure databases

ProteinModelPortaliP63778
SMRiP63778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000021225
OMAiYWTSAAE

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 3 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P63778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVVPENFVP GLDGVVAFTT EIAEPDKDGG ALRYRGVDIE DLVSQRVTFG
60 70 80 90 100
DVWALLVDGN FGSGLPPAEP FPLPIHSGDV RVDVQAGLAM LAPIWGYAPL
110 120 130 140 150
LDIDDATARQ QLARASVMAL SYVAQSARGI YQPAVPQRII DECSTVTARF
160 170 180 190 200
MTRWQGEPDP RHIEAIDAYW VSAAEHGMNA STFTARVIAS TGADVAAALS
210 220 230 240 250
GAIGAMSGPL HGGAPARVLP MLDEVERAGD ARSVVKGILD RGEKLMGFGH
260 270 280 290 300
RVYRAEDPRA RVLRAAAERL GAPRYEVAVA VEQAALSELR ERRPDRAIET
310 320 330 340 350
NVEFWAAVVL DFARVPANMM PAMFTCGRTA GWCAHILEQK RLGKLVRPSA
360 370
IYVGPGPRSP ESVDGWERVL TTA
Length:373
Mass (Da):40,147
Last modified:October 11, 2004 - v1
Checksum:iAABF5238CB79B54D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIT99511.1
RefSeqiNP_854570.1, NC_002945.3
WP_003898633.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42157; CDO42157; Mb0913c
PATRICifig|233413.5.peg.994

Similar proteinsi

Entry informationi

Entry nameiCISY2_MYCBO
AccessioniPrimary (citable) accession number: P63778
Secondary accession number(s): A0A1R3XWQ6, Q10529, X2BG39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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