Reviewed, UniProtKB/Swiss-Prot P63760 (FTSW_MYCTU)

Names and origin

Protein names

Recommended name:
    Probable cell division protein ftsW

Gene names

Name:	ftsW
Synonyms:	rodA
Ordered Locus Names:	Rv0017c, MT0020
ORF Names:	MTCY10H4.17c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ftsW/rodA/spoVE family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Probable cell division protein ftsW		PRO_0000062710
Regions
	Transmembrane	20 – 40	21	Potential
	Transmembrane	50 – 70	21	Potential
	Transmembrane	76 – 96	21	Potential
	Transmembrane	115 – 135	21	Potential
	Transmembrane	146 – 166	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	226 – 246	21	Potential
	Transmembrane	247 – 267	21	Potential
	Transmembrane	268 – 288	21	Potential
	Transmembrane	312 – 332	21	Potential
	Transmembrane	344 – 364	21	Potential
	Transmembrane	386 – 406	21	Potential
	Transmembrane	418 – 438	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P63760-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: F4DBB2AB46ED72BA	FASTA	469	50,611
	10 20 30 40 50 60 MTTRLQAPVA VTPPLPTRRN AELLLLCFAA VITFAALLVV QANQDQGVPW DLTSYGLAFL 70 80 90 100 110 120 TLFGSAHLAI RRFAPYTDPL LLPVVALLNG LGLVMIHRLD LVDNEIGEHR HPSANQQMLW 130 140 150 160 170 180 TLVGVAAFAL VVTFLKDHRQ LARYGYICGL AGLVFLAVPA LLPAALSEQN GAKIWIRLPG 190 200 210 220 230 240 FSIQPAEFSK ILLLIFFSAV LVAKRGLFTS AGKHLLGMTL PRPRDLAPLL AAWVISVGVM 250 260 270 280 290 300 VFEKDLGASL LLYTSFLVVV YLATQRFSWV VIGLTLFAAG TLVAYFIFEH VRLRVQTWLD 310 320 330 340 350 360 PFADPDGTGY QIVQSLFSFA TGGIFGTGLG NGQPDTVPAA STDFIIAAFG EELGLVGLTA 370 380 390 400 410 420 ILMLYTIVII RGLRTAIATR DSFGKLLAAG LSSTLAIQLF IVVGGVTRLI PLTGLTTPWM 430 440 450 460 SYGGSSLLAN YILLAILARI SHGARRPLRT RPRNKSPITA AGTEVIERV

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAB02437.1. AE000516 Genomic DNA. Translation: AAK44242.1.
PIR	G70699.
RefSeq	NP_214531.1. NP_334428.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	887075. 922468.
GenomeReviews	Gene locus MT0020 in contig AE000516_GR.
KEGG	mtc:MT0020. mtu:Rv0017c.
TIGR	MT0020.
Organism-specific databases
TubercuList	Rv0017c.
Phylogenomic databases
HOGENOM	HBG729614.
OMA	HSDFILA.
Family and domain databases
InterPro	IPR001182. Cell_cycle. IPR018365. Cell_cycle_FtsW-rel_CS. [Graphical view]
Pfam	PF01098. FTSW_RODA_SPOVE. 1 hit. [Graphical view]
PROSITE	PS00428. FTSW_RODA_SPOVE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSW_MYCTU

Accession

Primary (citable) accession number: P63760
Secondary accession number(s): P71587

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)