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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:BQ2027_MB2905C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907411 – 306Phosphatidate cytidylyltransferaseAdd BLAST306

Structurei

3D structure databases

ProteinModelPortaliP63759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006170.
KOiK00981.
OMAiFGKHPMA.

Family and domain databases

InterProiView protein in InterPro
IPR000374. PC_trans.
PROSITEiView protein in PROSITE
PS01315. CDS. 1 hit.

Sequencei

Sequence statusi: Complete.

P63759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNDAGTGN PAEQPARGAK QQPATETSRA GRDLRAAIVV GLSIGLVLIA
60 70 80 90 100
VLVFVPRVWV AIVAVATLVA THEVVRRLRE AGYLIPVIPL LIGGQAAVWL
110 120 130 140 150
TWPFGAVGAL AGFGGMVVVC MIWRLFMQDS VTRPTTGGAP SPGNYLSDVS
160 170 180 190 200
ATVFLAVWVP LFCSFGAMLV YPENGSGWVF CMMIAVIASD VGGYAVGVLF
210 220 230 240 250
GKHPMVPTIS PKKSWEGFAG SLVCGITATI ITATFLVGKT PWIGALLGVL
260 270 280 290 300
FVLTTALGDL VESQVKRDLG IKDMGRLLPG HGGLMDRLDG ILPSAVAAWI

VLTLLP
Length:306
Mass (Da):32,035
Last modified:October 11, 2004 - v1
Checksum:i8FA81A108035099F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU01526.1.
RefSeqiNP_856550.1. NC_002945.3.
WP_003414661.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO44172; CDO44172; Mb2905c.
KEGGimbo:Mb2905c.
PATRICifig|233413.5.peg.3188.

Similar proteinsi

Entry informationi

Entry nameiCDSA_MYCBO
AccessioniPrimary (citable) accession number: P63759
Secondary accession number(s): A0A1R3Y398, Q10807, X2BLT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families