P63759 (CDSA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	Mb2905c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Phosphatidate cytidylyltransferase		PRO_0000090741
Regions
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Transmembrane	180 – 200	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	241 – 261	21	Helical; Potential
	Transmembrane	285 – 305	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P63759 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 8FA81A108035099F	FASTA	306	32,035
	10 20 30 40 50 60 MTTNDAGTGN PAEQPARGAK QQPATETSRA GRDLRAAIVV GLSIGLVLIA VLVFVPRVWV 70 80 90 100 110 120 AIVAVATLVA THEVVRRLRE AGYLIPVIPL LIGGQAAVWL TWPFGAVGAL AGFGGMVVVC 130 140 150 160 170 180 MIWRLFMQDS VTRPTTGGAP SPGNYLSDVS ATVFLAVWVP LFCSFGAMLV YPENGSGWVF 190 200 210 220 230 240 CMMIAVIASD VGGYAVGVLF GKHPMVPTIS PKKSWEGFAG SLVCGITATI ITATFLVGKT 250 260 270 280 290 300 PWIGALLGVL FVLTTALGDL VESQVKRDLG IKDMGRLLPG HGGLMDRLDG ILPSAVAAWI VLTLLP

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248344 Genomic DNA. Translation: CAD96592.1.
RefSeq	NP_856550.1. NC_002945.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000015167; EBMYCP00000015002; EBMYCG00000015164.
GeneID	1092203.
GenomeReviews	Gene locus Mb2905c in contig BX248333_GR.
KEGG	mbo:Mb2905c.
PATRIC	18008112. VBIMycBov88188_3188.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017496.
HOGENOM	HBG732679.
OMA	MPQAIAT.
ProtClustDB	CLSK792142.
Enzyme and pathway databases
BioCyc	MBOV233413:MB2905C-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCBO

Accession

Primary (citable) accession number: P63759
Secondary accession number(s): Q10807

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program