Reviewed, UniProtKB/Swiss-Prot P63758 (CDSA_MYCTU)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	Rv2881c, MT2948
ORF Names:	MTCY274.12c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Phosphatidate cytidylyltransferase		PRO_0000090743
Regions
	Transmembrane	36 – 56	21	Potential
	Transmembrane	82 – 102	21	Potential
	Transmembrane	103 – 123	21	Potential
	Transmembrane	151 – 171	21	Potential
	Transmembrane	180 – 200	21	Potential
	Transmembrane	218 – 238	21	Potential
	Transmembrane	241 – 261	21	Potential
	Transmembrane	285 – 305	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P63758-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 8FA81A108035099F	FASTA	306	32,035
	10 20 30 40 50 60 MTTNDAGTGN PAEQPARGAK QQPATETSRA GRDLRAAIVV GLSIGLVLIA VLVFVPRVWV 70 80 90 100 110 120 AIVAVATLVA THEVVRRLRE AGYLIPVIPL LIGGQAAVWL TWPFGAVGAL AGFGGMVVVC 130 140 150 160 170 180 MIWRLFMQDS VTRPTTGGAP SPGNYLSDVS ATVFLAVWVP LFCSFGAMLV YPENGSGWVF 190 200 210 220 230 240 CMMIAVIASD VGGYAVGVLF GKHPMVPTIS PKKSWEGFAG SLVCGITATI ITATFLVGKT 250 260 270 280 290 300 PWIGALLGVL FVLTTALGDL VESQVKRDLG IKDMGRLLPG HGGLMDRLDG ILPSAVAAWI VLTLLP

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842581 Genomic DNA. Translation: CAA98357.1. AE000516 Genomic DNA. Translation: AAK47273.1. Different initiation.
PIR	D70924.
RefSeq	NP_217397.1. NP_337459.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	888910. 925332.
GenomeReviews	Gene locus MT2948 in contig AE000516_GR. Gene locus Rv2881c in contig AL123456_GR.
KEGG	mtc:MT2948. mtu:Rv2881c.
TIGR	MT2948.
Organism-specific databases
TubercuList	Rv2881c.
Phylogenomic databases
HOGENOM	P63758.
OMA	FGKHPMA.
Enzyme and pathway databases
BRENDA	2.7.7.41. 809.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCTU

Accession

Primary (citable) accession number: P63758
Secondary accession number(s): Q10807

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)