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P63758 (CDSA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene names
Name:cdsA
Ordered Locus Names:Rv2881c, MT2948
ORF Names:MTCY274.12c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the CDS family.

Sequence caution

The sequence AAK47273.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Phosphatidate cytidylyltransferase
PRO_0000090743

Regions

Transmembrane36 – 5621Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane241 – 26121Helical; Potential
Transmembrane285 – 30521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P63758 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8FA81A108035099F

FASTA30632,035
        10         20         30         40         50         60 
MTTNDAGTGN PAEQPARGAK QQPATETSRA GRDLRAAIVV GLSIGLVLIA VLVFVPRVWV 

        70         80         90        100        110        120 
AIVAVATLVA THEVVRRLRE AGYLIPVIPL LIGGQAAVWL TWPFGAVGAL AGFGGMVVVC 

       130        140        150        160        170        180 
MIWRLFMQDS VTRPTTGGAP SPGNYLSDVS ATVFLAVWVP LFCSFGAMLV YPENGSGWVF 

       190        200        210        220        230        240 
CMMIAVIASD VGGYAVGVLF GKHPMVPTIS PKKSWEGFAG SLVCGITATI ITATFLVGKT 

       250        260        270        280        290        300 
PWIGALLGVL FVLTTALGDL VESQVKRDLG IKDMGRLLPG HGGLMDRLDG ILPSAVAAWI 


VLTLLP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842581 Genomic DNA. Translation: CAA98357.1.
AE000516 Genomic DNA. Translation: AAK47273.1. Different initiation.
AL123456 Genomic DNA. Translation: CCP45683.1.
PIRD70924.
RefSeqNP_217397.1. NC_000962.3.
NP_337459.1. NC_002755.2.
YP_006516333.1. NC_018143.1.

3D structure databases

ProteinModelPortalP63758.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2881c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK47273; AAK47273; MT2948.
GeneID13317673.
888910.
925332.
KEGGmtc:MT2948.
mtu:Rv2881c.
mtv:RVBD_2881c.
PATRIC18128254. VBIMycTub22151_3226.

Organism-specific databases

TubercuListRv2881c.

Phylogenomic databases

eggNOGCOG0575.
HOGENOMHOG000006170.
KOK00981.
OMAGKSWEGF.
ProtClustDBCLSK792142.

Enzyme and pathway databases

UniPathwayUPA00557; UER00614.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_MYCTU
AccessionPrimary (citable) accession number: P63758
Secondary accession number(s): L0TDN0, Q10807
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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