P63758 (CDSA_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 60.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphatidate cytidylyltransferase EC=2.7.7.41 Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name=CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase | ||||||
| Gene names |
| ||||||
| Organism | Mycobacterium tuberculosis [Reference proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex![]() |
Protein attributes
| Sequence length | 306 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| Pathway | |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the CDS family. |
| Sequence caution | The sequence AAK47273.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | CDP-diacylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway growthInferred from mutant phenotype PubMed 12657046. Source: MTBBASE |
| Cellular_component | cell wall Inferred from direct assay PubMed 20825248. Source: MTBBASE integral to membraneInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 306 | 306 | Phosphatidate cytidylyltransferase | PRO_0000090743 | |||||
Regions | |||||||||
| Transmembrane | 36 – 56 | 21 | Helical; Potential | ||||||
| Transmembrane | 82 – 102 | 21 | Helical; Potential | ||||||
| Transmembrane | 103 – 123 | 21 | Helical; Potential | ||||||
| Transmembrane | 151 – 171 | 21 | Helical; Potential | ||||||
| Transmembrane | 180 – 200 | 21 | Helical; Potential | ||||||
| Transmembrane | 218 – 238 | 21 | Helical; Potential | ||||||
| Transmembrane | 241 – 261 | 21 | Helical; Potential | ||||||
| Transmembrane | 285 – 305 | 21 | Helical; Potential | ||||||
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842581 Genomic DNA. Translation: CAA98357.1. AE000516 Genomic DNA. Translation: AAK47273.1. Different initiation. AL123456 Genomic DNA. Translation: CCP45683.1. |
| PIR | D70924. |
| RefSeq | NP_217397.1. NC_000962.3. NP_337459.1. NC_002755.2. YP_006516333.1. NC_018143.1. |
3D structure databases | |
| ProteinModelPortal | P63758. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 83332.Rv2881c. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAK47273; AAK47273; MT2948. |
| GeneID | 13317673. 888910. 925332. |
| KEGG | mtc:MT2948. mtu:Rv2881c. mtv:RVBD_2881c. |
| PATRIC | 18128254. VBIMycTub22151_3226. |
Organism-specific databases | |
| TubercuList | Rv2881c. |
Phylogenomic databases | |
| eggNOG | COG0575. |
| HOGENOM | HOG000006170. |
| KO | K00981. |
| OMA | GKSWEGF. |
| ProtClustDB | CLSK792142. |
Enzyme and pathway databases | |
| UniPathway | UPA00557; UER00614. |
Family and domain databases | |
| InterPro | IPR000374. PC_trans. [Graphical view] |
| Pfam | PF01148. CTP_transf_1. 1 hit. [Graphical view] |
| PROSITE | PS01315. CDS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDSA_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P63758 Secondary accession number(s): L0TDN0, Q10807 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
