P63754 (PGSA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA2
Synonyms:	pgsA
Ordered Locus Names:	Mb1853

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase		PRO_0000056780
Regions
	Transmembrane	27 – 47	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	157 – 177	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P63754 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 36079C2FD2D6F91B	FASTA	209	22,911
	10 20 30 40 50 60 MEPVLTQNRV LTVPNMLSVI RLALIPAFVY VVLSAHANGW GVAILVFSGV SDWADGKIAR 70 80 90 100 110 120 LLNQSSRLGA LLDPAVDRLY MVTVPIVFGL SGIVPWWFVL TLLTRDALLA GTLPLLWSRG 130 140 150 160 170 180 LSALPVTYVG KAATFGFMVG FPTILLGQCD PLWSHVLLAC GWAFLIWGMY AYLWAFVLYA 190 200 VQMTMVVRQM PKLKGRAHRP AAQNAGERG

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248340 Genomic DNA. Translation: CAD94556.1.
RefSeq	NP_855505.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63754.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000014582; EBMYCP00000014417; EBMYCG00000014579.
GeneID	1092973.
GenomeReviews	Gene locus Mb1853 in contig BX248333_GR.
KEGG	mbo:Mb1853.
PATRIC	18005777. VBIMycBov88188_2033.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016087.
HOGENOM	HBG686655.
OMA	WAVAILM.
ProtClustDB	CLSK791412.
Enzyme and pathway databases
BioCyc	MBOV233413:MB1853-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
KO	K00995.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_MYCBO

Accession

Primary (citable) accession number: P63754
Secondary accession number(s): Q50611

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program