Reviewed, UniProtKB/Swiss-Prot P63753 (PGSA_MYCTU)

Names and origin

Protein names

Recommended name:
    Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA2
Synonyms:	pgsA
Ordered Locus Names:	Rv1822, MT1870
ORF Names:	MTCY1A11.21c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase		PRO_0000056779
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	82 – 102	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	157 – 177	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P63753-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 36079C2FD2D6F91B	FASTA	209	22,911
	10 20 30 40 50 60 MEPVLTQNRV LTVPNMLSVI RLALIPAFVY VVLSAHANGW GVAILVFSGV SDWADGKIAR 70 80 90 100 110 120 LLNQSSRLGA LLDPAVDRLY MVTVPIVFGL SGIVPWWFVL TLLTRDALLA GTLPLLWSRG 130 140 150 160 170 180 LSALPVTYVG KAATFGFMVG FPTILLGQCD PLWSHVLLAC GWAFLIWGMY AYLWAFVLYA 190 200 VQMTMVVRQM PKLKGRAHRP AAQNAGERG

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842577 Genomic DNA. Translation: CAB01479.1. AE000516 Genomic DNA. Translation: AAK46143.1.
PIR	G70720.
RefSeq	NP_216338.1. NP_336329.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	885126. 923624.
GenomeReviews	Gene locus MT1870 in contig AE000516_GR. Gene locus Rv1822 in contig AL123456_GR.
KEGG	mtc:MT1870. mtu:Rv1822.
TIGR	MT1870.
Organism-specific databases
TubercuList	Rv1822.
Phylogenomic databases
HOGENOM	P63753.
OMA	WAVAILM.
Enzyme and pathway databases
BRENDA	2.7.8.5. 809.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_MYCTU

Accession

Primary (citable) accession number: P63753
Secondary accession number(s): Q50611

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)