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P63751 (CDH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene names
Name:cdh
Ordered Locus Names:Rv2289, MT2346
ORF Names:MTCY339.21c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319

Pathway

Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319

Subcellular location

Cell membrane; Single-pass membrane protein Potential HAMAP MF_00319.

Sequence similarities

Belongs to the cdh family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from genetic interaction. Source: MTBBASE

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionCDP-diacylglycerol diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Probable CDP-diacylglycerol pyrophosphatase HAMAP MF_00319
PRO_0000198580

Regions

Transmembrane10 – 3021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P63751 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: D2884BE3B6F1489D

FASTA26028,608
        10         20         30         40         50         60 
MPKSRRAVSL SVLIGAVIAA LAGALIAVTV PARPNRPEAD REALWKIVHD RCEFGYRRTG 

        70         80         90        100        110        120 
AYAPCTFVDE QSGTALYKAD FDPYQFLLIP LARITGIEDP ALRESAGRNY LYDAWAARFL 

       130        140        150        160        170        180 
VTARLNNSLP ESDVVLTINP KNARTQDQLH IHISCSSPTT SAALRNVDTS EYVGWKQLPI 

       190        200        210        220        230        240 
DLGGRRFQGL AVDTKAFESR NLFRDIYLKV TADGKKMENA SIAVANVAQD QFLLLLAEGT 

       250        260 
EDQPVAAETL QDHDCSITKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAB00999.1.
AE000516 Genomic DNA. Translation: AAK46631.1.
PIRE70732.
RefSeqNP_216805.1. NC_000962.2.
NP_336817.1. NC_002755.2.

3D structure databases

ProteinModelPortalP63751.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002577; EBMYCP00000002577; EBMYCG00000002575.
EBMYCT00000070689; EBMYCP00000068748; EBMYCG00000070684.
GeneID887342.
924076.
GenomeReviewsGene locus MT2346 in contig AE000516_GR.
Gene locus Rv2289 in contig AL123456_GR.
KEGGmtc:MT2346.
mtu:Rv2289.
PATRIC18126908. VBIMycTub22151_2564.
TIGRMT2346.

Organism-specific databases

TubercuListRv2289.

Phylogenomic databases

GeneTreeEBGT00050000018626.
HOGENOMHBG565233.
OMADINGPLQ.
PhylomeDBP63751.
ProtClustDBPRK05471.

Family and domain databases

HAMAPMF_00319. Cdh.
[Tree]
InterProIPR003763. CDP-diacylglyc_Pase.
[Graphical view]
KOK01521.
PfamPF02611. CDH. 1 hit.
[Graphical view]
PIRSFPIRSF001273. CDH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDH_MYCTU
AccessionPrimary (citable) accession number: P63751
Secondary accession number(s): Q50676
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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