Reviewed, UniProtKB/Swiss-Prot P63751 (CDH_MYCTU)

Names and origin

Protein names

Recommended name:
    Probable CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	Rv2289, MT2346
ORF Names:	MTCY339.21c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Probable CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198580
Regions
	Transmembrane	10 – 30	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P63751-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D2884BE3B6F1489D	FASTA	260	28,608
	10 20 30 40 50 60 MPKSRRAVSL SVLIGAVIAA LAGALIAVTV PARPNRPEAD REALWKIVHD RCEFGYRRTG 70 80 90 100 110 120 AYAPCTFVDE QSGTALYKAD FDPYQFLLIP LARITGIEDP ALRESAGRNY LYDAWAARFL 130 140 150 160 170 180 VTARLNNSLP ESDVVLTINP KNARTQDQLH IHISCSSPTT SAALRNVDTS EYVGWKQLPI 190 200 210 220 230 240 DLGGRRFQGL AVDTKAFESR NLFRDIYLKV TADGKKMENA SIAVANVAQD QFLLLLAEGT 250 260 EDQPVAAETL QDHDCSITKS

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842579 Genomic DNA. Translation: CAB00999.1. AE000516 Genomic DNA. Translation: AAK46631.1.
PIR	E70732.
RefSeq	NP_216805.1. NP_336817.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	887342. 924076.
GenomeReviews	Gene locus MT2346 in contig AE000516_GR. Gene locus Rv2289 in contig AL123456_GR.
KEGG	mtc:MT2346. mtu:Rv2289.
TIGR	MT2346.
Organism-specific databases
TubercuList	Rv2289.
Phylogenomic databases
HOGENOM	P63751.
OMA	P63751. EIQDHEC.
Enzyme and pathway databases
BRENDA	3.6.1.26. 809.
Family and domain databases
HAMAP	MF_00319. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase_bac. [Graphical view]
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_MYCTU

Accession

Primary (citable) accession number: P63751
Secondary accession number(s): Q50676

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)