P63717 (CP138_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome P450 138
EC=1.14.-.-

Gene names

Name:	cyp138
Ordered Locus Names:	Rv0136, MT0144
ORF Names:	MTCI5.10

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Putative cytochrome P450 138		PRO_0000052298
Sites
	Metal binding	388	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63717 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 0E433656428A64EB	FASTA	441	49,261
	10 20 30 40 50 60 MSEVVTAAPA PPVVRLPPAV RGPKLFQGLA FVVSRRRLLG RFVRRYGKAF TANILMYGRV 70 80 90 100 110 120 VVVADPQLAR QVFTSSPEEL GNIQPNLSRM FGSGSVFALD GDDHRRRRRL LAPPFHGKSM 130 140 150 160 170 180 KNYETIIEEE TLRETANWPQ GQAFATLPSM MHITLNAILR AIFGAGGSEL DELRRLIPPW 190 200 210 220 230 240 VTLGSRLAAL PKPKRDYGRL SPWGRLAEWR RQYDTVIDKL IEAERADPNF ADRTDVLALM 250 260 270 280 290 300 LRSTYDDGSI MSRKDIGDEL LTLLAAGHET TAATLGWAFE RLSRHPDVLA ALVEEVDNGG 310 320 330 340 350 360 HELRQAAILE VQRARTVIDF AARRVNPPVY QLGEWVIPRG YSIIINIAQI HGDPDVFPQP 370 380 390 400 410 420 DRFDPQRYIG SKPSPFAWIP FGGGTRRCVG AAFANMEMDV VLRTVLRHFT LETTTAAGER 430 440 SHGRGVAFTP KDGGRVVMRR R

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAB07042.1. AE000516 Genomic DNA. Translation: AAK44368.1.
PIR	C70616.
RefSeq	NP_214650.1. NC_000962.2. NP_334554.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P63717.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002725; EBMYCP00000002725; EBMYCG00000002723. EBMYCT00000070681; EBMYCP00000068740; EBMYCG00000070676.
GeneID	886868. 923011.
GenomeReviews	Gene locus MT0144 in contig AE000516_GR. Gene locus Rv0136 in contig AL123456_GR.
KEGG	mtc:MT0144. mtu:Rv0136.
PATRIC	18122045. VBIMycTub22151_0157.
TIGR	MT0144.
Organism-specific databases
TubercuList	Rv0136.
Phylogenomic databases
GeneTree	EBGT00050000015571.
HOGENOM	HBG569300.
OMA	MRITLNA.
PhylomeDB	P63717.
ProtClustDB	CLSK790291.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K00517.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP138_MYCTU

Accession

Primary (citable) accession number: P63717
Secondary accession number(s): P96813

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program