P63715 (C135B_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome P450 135B1
EC=1.14.-.-

Gene names

Name:	CYP135B1
Ordered Locus Names:	Rv0568, MT0594
ORF Names:	MTV039.06

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: MTBBASE
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Putative cytochrome P450 135B1		PRO_0000052293
Sites
	Metal binding	388	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63715 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: B7E2898BEE80863F	FASTA	472	50,688
	10 20 30 40 50 60 MSGTSSMGLP PGPRLSGSVQ AVLMLRHGLR FLTACQRRYG SVFTLHVAGF GHMVYLSDPA 70 80 90 100 110 120 AIKTVFAGNP SVFHAGEANS MLAGLLGDSS LLLIDDDVHR DRRRLMSPPF HRDAVARQAG 130 140 150 160 170 180 PIAEIAAANI AGWPMAKAFA VAPKMSEITL EVILRTVIGA SDPVRLAALR KVMPRLLNVG 190 200 210 220 230 240 PWATLALANP SLLNNRLWSR LRRRIEEADA LLYAEIADRR ADPDLAARTD TLAMLVRAAD 250 260 270 280 290 300 EDGRTMTERE LRDQLITLLV AGHDTTATGL SWALERLTRH PVTLAKAVQA ADASAAGDPA 310 320 330 340 350 360 GDEYLDAVAK ETLRIRPVVY DVGRVLTEAV EVAGYRLPAG VMVVPAIGLV HASAQLYPDP 370 380 390 400 410 420 ERFDPDRMVG ATLSPTTWLP FGGGNRRCLG ATFAMVEMRV VLREILRRVE LSTTTTSGER 430 440 450 460 470 PKLKHVIMVP HRGARIRVRA TRDVSATSQA TAQGAGCPAA RGGGPSRAVG SQ

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842573 Genomic DNA. Translation: CAA17439.1. AE000516 Genomic DNA. Translation: AAK44817.1.
PIR	G70932.
RefSeq	NP_215082.1. NC_000962.2. NP_335003.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P63715.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000723; EBMYCP00000000723; EBMYCG00000000723. EBMYCT00000070661; EBMYCP00000068720; EBMYCG00000070656.
GeneID	887654. 924986.
GenomeReviews	Gene locus MT0594 in contig AE000516_GR. Gene locus Rv0568 in contig AL123456_GR.
KEGG	mtc:MT0594. mtu:Rv0568.
PATRIC	18123008. VBIMycTub22151_0637.
TIGR	MT0594.
Organism-specific databases
TubercuList	Rv0568.
Phylogenomic databases
GeneTree	EBGT00050000015571.
HOGENOM	HBG569300.
OMA	SFHGERM.
PhylomeDB	P63715.
ProtClustDB	CLSK790438.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K00517.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C135B_MYCTU

Accession

Primary (citable) accession number: P63715
Secondary accession number(s): O53765

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program