Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tagatose 1,6-diphosphate aldolase 2

Gene

lacD2

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase 2 (lacD2), Tagatose 1,6-diphosphate aldolase 1 (lacD1)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-1711-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase 2 (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase 2
Tagatose-bisphosphate aldolase 2
Gene namesi
Name:lacD2
Synonyms:lacD.2
Ordered Locus Names:spyM18_1987
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Tagatose 1,6-diphosphate aldolase 2PRO_0000203968Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP63706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P63706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITLTENKR KSMEKLSVDG VISALAFDQR GALKRMMAQH QTKEPTVEQI
60 70 80 90 100
EELKSLVSEE LTPFASSILL DPEYGLPASR VRSEEAGLLL AYEKTGYDAT
110 120 130 140 150
TTSRLPDCLD VWSAKRIKEA GAEAVKFLLY YDIDGDQDVN EQKKAYIERI
160 170 180 190 200
GSECRAEDIP FYLEILTYDE KIADNASPEF AKVKAHKVNE AMKVFSKERF
210 220 230 240 250
GVDVLKVEVP VNMKFVEGFA DGEVLFTKEE AAQAFRDQEA STDLPYIYLS
260 270 280 290 300
AGVSAKLFQD TLVFAAESGA KFNGVLCGRA TWAGSVKVYI EEGPQAAREW
310 320
LRTEGFKNID ELNKVLDKTA SPWTEKM
Length:327
Mass (Da):36,577
Last modified:October 11, 2004 - v1
Checksum:i4E179B441A90543E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009949 Genomic DNA. Translation: AAL98473.1.
RefSeqiWP_002982755.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL98473; AAL98473; spyM18_1987.
KEGGispm:spyM18_1987.
PATRICi19750424. VBIStrPyo4396_1778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009949 Genomic DNA. Translation: AAL98473.1.
RefSeqiWP_002982755.1. NC_003485.1.

3D structure databases

ProteinModelPortaliP63706.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL98473; AAL98473; spyM18_1987.
KEGGispm:spyM18_1987.
PATRICi19750424. VBIStrPyo4396_1778.

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciSPYO186103:GHJG-1711-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLACD2_STRP8
AccessioniPrimary (citable) accession number: P63706
Secondary accession number(s): Q99Y15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.