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Protein

Tagatose 1,6-diphosphate aldolase 2

Gene

lacD2

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC), Tagatose-6-phosphate kinase (fruB)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase 2 (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase 2
Tagatose-bisphosphate aldolase 2
Gene namesi
Name:lacD2
Synonyms:lacD.2
Ordered Locus Names:SPy_1919, M5005_Spy1635
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002039651 – 327Tagatose 1,6-diphosphate aldolase 2Add BLAST327

Proteomic databases

PaxDbiP63705.
PRIDEiP63705.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1919.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 15Combined sources9
Beta strandi21 – 27Combined sources7
Helixi31 – 38Combined sources8
Helixi47 – 61Combined sources15
Helixi62 – 64Combined sources3
Beta strandi65 – 70Combined sources6
Turni72 – 74Combined sources3
Helixi76 – 80Combined sources5
Beta strandi87 – 91Combined sources5
Helixi114 – 119Combined sources6
Beta strandi123 – 131Combined sources9
Helixi137 – 157Combined sources21
Beta strandi161 – 167Combined sources7
Helixi178 – 195Combined sources18
Helixi198 – 200Combined sources3
Beta strandi203 – 207Combined sources5
Helixi213 – 215Combined sources3
Turni217 – 219Combined sources3
Helixi228 – 239Combined sources12
Beta strandi246 – 248Combined sources3
Helixi255 – 268Combined sources14
Beta strandi274 – 277Combined sources4
Helixi279 – 282Combined sources4
Helixi285 – 292Combined sources8
Helixi294 – 319Combined sources26
Helixi323 – 325Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JRKX-ray1.97A/B/C/D/E/F/G/H6-327[»]
3MHFX-ray1.87A/B/C/D2-327[»]
3MHGX-ray1.92A/B/C/D2-327[»]
ProteinModelPortaliP63705.
SMRiP63705.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63705.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

eggNOGiCOG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P63705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITLTENKR KSMEKLSVDG VISALAFDQR GALKRMMAQH QTKEPTVEQI
60 70 80 90 100
EELKSLVSEE LTPFASSILL DPEYGLPASR VRSEEAGLLL AYEKTGYDAT
110 120 130 140 150
TTSRLPDCLD VWSAKRIKEA GAEAVKFLLY YDIDGDQDVN EQKKAYIERI
160 170 180 190 200
GSECRAEDIP FYLEILTYDE KIADNASPEF AKVKAHKVNE AMKVFSKERF
210 220 230 240 250
GVDVLKVEVP VNMKFVEGFA DGEVLFTKEE AAQAFRDQEA STDLPYIYLS
260 270 280 290 300
AGVSAKLFQD TLVFAAESGA KFNGVLCGRA TWAGSVKVYI EEGPQAAREW
310 320
LRTEGFKNID ELNKVLDKTA SPWTEKM
Length:327
Mass (Da):36,577
Last modified:October 11, 2004 - v1
Checksum:i4E179B441A90543E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34623.1.
CP000017 Genomic DNA. Translation: AAZ52253.1.
RefSeqiNP_269902.1. NC_002737.2.

Genome annotation databases

EnsemblBacteriaiAAK34623; AAK34623; SPy_1919.
AAZ52253; AAZ52253; M5005_Spy1635.
GeneIDi901603.
KEGGispy:SPy_1919.
spz:M5005_Spy1635.
PATRICi19717248. VBIStrPyo79812_1668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34623.1.
CP000017 Genomic DNA. Translation: AAZ52253.1.
RefSeqiNP_269902.1. NC_002737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JRKX-ray1.97A/B/C/D/E/F/G/H6-327[»]
3MHFX-ray1.87A/B/C/D2-327[»]
3MHGX-ray1.92A/B/C/D2-327[»]
ProteinModelPortaliP63705.
SMRiP63705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_1919.

Proteomic databases

PaxDbiP63705.
PRIDEiP63705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK34623; AAK34623; SPy_1919.
AAZ52253; AAZ52253; M5005_Spy1635.
GeneIDi901603.
KEGGispy:SPy_1919.
spz:M5005_Spy1635.
PATRICi19717248. VBIStrPyo79812_1668.

Phylogenomic databases

eggNOGiCOG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.

Miscellaneous databases

EvolutionaryTraceiP63705.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLACD2_STRP1
AccessioniPrimary (citable) accession number: P63705
Secondary accession number(s): Q48WM2, Q99Y15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.