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Protein

Tagatose 1,6-diphosphate aldolase 1

Gene

lacD1

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC), Tagatose-6-phosphate kinase (fruB)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1405-MONOMER.
SPYO293653:GHFC-1466-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase 1 (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase 1
Tagatose-bisphosphate aldolase 1
Gene namesi
Name:lacD1
Synonyms:lacD.1
Ordered Locus Names:SPy_1704, M5005_Spy1395
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Tagatose 1,6-diphosphate aldolase 1PRO_0000203961Add
BLAST

Proteomic databases

PaxDbiP63703.

Interactioni

Protein-protein interaction databases

IntActiP63703. 1 interaction.
MINTiMINT-3382546.
STRINGi160490.SPy_1704.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 139Combined sources
Beta strandi19 – 257Combined sources
Helixi29 – 357Combined sources
Turni36 – 383Combined sources
Beta strandi39 – 413Combined sources
Helixi45 – 5915Combined sources
Helixi60 – 623Combined sources
Beta strandi64 – 685Combined sources
Turni70 – 723Combined sources
Helixi74 – 774Combined sources
Beta strandi85 – 895Combined sources
Helixi112 – 1176Combined sources
Beta strandi121 – 1299Combined sources
Helixi135 – 15521Combined sources
Beta strandi159 – 1657Combined sources
Helixi176 – 1794Combined sources
Helixi182 – 19211Combined sources
Helixi196 – 1983Combined sources
Beta strandi201 – 2055Combined sources
Helixi211 – 2133Combined sources
Helixi226 – 23914Combined sources
Beta strandi244 – 2474Combined sources
Helixi253 – 26614Combined sources
Beta strandi272 – 2754Combined sources
Helixi277 – 2804Combined sources
Helixi283 – 2908Combined sources
Helixi292 – 3009Combined sources
Helixi302 – 31716Combined sources
Helixi321 – 3233Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MYOX-ray2.50A/B1-325[»]
ProteinModelPortaliP63703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

eggNOGiCOG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiWANGVES.
OrthoDBiEOG6SR92W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P63703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET
60 70 80 90 100
LKVLVSEELT PYASSILLDP EYGLLATKVR ANQTGLLLAY EKTGYDATTT
110 120 130 140 150
SRLPDCLVEW SVKRLKAAGA DAIKFLLYYD VDGDEQINLQ KQAYIERIGS
160 170 180 190 200
ECTAEDIPFF LELLSYDERI SDNNSAAYAK LKPHKVNGAM SVFSDKRFGV
210 220 230 240 250
DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS HLPYIYLSAG
260 270 280 290 300
VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
310 320
TEGFQNIDEL NRVLEETASP WTEKI
Length:325
Mass (Da):36,011
Last modified:October 11, 2004 - v1
Checksum:i7B3A1B69AF3C471E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34454.1.
CP000017 Genomic DNA. Translation: AAZ52013.1.
RefSeqiNP_269733.1. NC_002737.2.

Genome annotation databases

EnsemblBacteriaiAAK34454; AAK34454; SPy_1704.
AAZ52013; AAZ52013; M5005_Spy1395.
GeneIDi901944.
KEGGispy:SPy_1704.
spz:M5005_Spy1395.
PATRICi19716860. VBIStrPyo79812_1482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34454.1.
CP000017 Genomic DNA. Translation: AAZ52013.1.
RefSeqiNP_269733.1. NC_002737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MYOX-ray2.50A/B1-325[»]
ProteinModelPortaliP63703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63703. 1 interaction.
MINTiMINT-3382546.
STRINGi160490.SPy_1704.

Proteomic databases

PaxDbiP63703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK34454; AAK34454; SPy_1704.
AAZ52013; AAZ52013; M5005_Spy1395.
GeneIDi901944.
KEGGispy:SPy_1704.
spz:M5005_Spy1395.
PATRICi19716860. VBIStrPyo79812_1482.

Phylogenomic databases

eggNOGiCOG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiWANGVES.
OrthoDBiEOG6SR92W.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciSPYO160490:GJ81-1405-MONOMER.
SPYO293653:GHFC-1466-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiLACD1_STRP1
AccessioniPrimary (citable) accession number: P63703
Secondary accession number(s): Q48XB2, Q99YH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.