ID   SCOA_MYCBO              Reviewed;         248 AA.
AC   P63649; A0A1R3Y1S8; O06167; X2BKZ9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE            EC=2.8.3.5;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE            Short=OXCT A;
GN   Name=scoA; OrderedLocusNames=BQ2027_MB2532C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU01148.1; -; Genomic_DNA.
DR   RefSeq; NP_856177.1; NC_002945.3.
DR   RefSeq; WP_003412786.1; NC_002945.4.
DR   AlphaFoldDB; P63649; -.
DR   SMR; P63649; -.
DR   GeneID; 45426498; -.
DR   PATRIC; fig|233413.5.peg.2787; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0008260; F:succinyl-CoA:3-oxo-acid CoA-transferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR02429; pcaI_scoA_fam; 1.
DR   PANTHER; PTHR13707; KETOACID-COENZYME A TRANSFERASE; 1.
DR   PANTHER; PTHR13707:SF57; SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE SUBUNIT B; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..248
FT                   /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT                   transferase subunit A"
FT                   /id="PRO_0000157912"
FT   BINDING         24..30
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  26276 MW;  81340193CC48EBD1 CRC64;
     MDKVVATAAE AVADIANGSS LAVGGFGLCG IPEALIAALV DSGVTDLETV SNNCGIDGVG
     LGLLLQHKRI RRTVSSYVGE NKEFARQFLA GELEVELTPQ GTLAERLRAG GMGIPAFYTP
     AGVGTQVADG GLPWRYDASG GVAVVSPAKE TREFDGVTYV LERGIRTDFA LVHAWQGDRH
     GNLMYRHAAA NFNPECASAG RITIAEVEHL VEPGEIDPAT VHTPGVFVHR VVHVPNPAKK
     IERETVRQ
//