P63649 (SCOA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A
EC=2.8.3.5

Alternative name(s):
Succinyl-CoA:3-oxoacid CoA-transferase
Short name=OXCT A

Gene names

Name:	scoA
Ordered Locus Names:	Mb2532c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
Subunit structure	Heterodimer of a subunit A and a subunit B By similarity.
Sequence similarities	Belongs to the 3-oxoacid CoA-transferase subunit A family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	3-oxoacid CoA-transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A		PRO_0000157912
Regions
	Region	24 – 30	7	CoA-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	P63649 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 81340193CC48EBD1	FASTA	248	26,276
	10 20 30 40 50 60 MDKVVATAAE AVADIANGSS LAVGGFGLCG IPEALIAALV DSGVTDLETV SNNCGIDGVG 70 80 90 100 110 120 LGLLLQHKRI RRTVSSYVGE NKEFARQFLA GELEVELTPQ GTLAERLRAG GMGIPAFYTP 130 140 150 160 170 180 AGVGTQVADG GLPWRYDASG GVAVVSPAKE TREFDGVTYV LERGIRTDFA LVHAWQGDRH 190 200 210 220 230 240 GNLMYRHAAA NFNPECASAG RITIAEVEHL VEPGEIDPAT VHTPGVFVHR VVHVPNPAKK IERETVRQ

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248342 Genomic DNA. Translation: CAD97393.1.
RefSeq	NP_856177.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63649.
SMR	P63649. Positions 3-247.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb2532c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD97393; CAD97393; Mb2532c.
GeneID	1090568.
KEGG	mbo:Mb2532c.
PATRIC	18007295. VBIMycBov88188_2787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1788.
HOGENOM	HOG000221244.
KO	K01028.
OMA	CGTTEYG.
ProtClustDB	CLSK872071.
Family and domain databases
InterPro	IPR012792. 3-oxoacid_CoA-transf_A. IPR004165. CoA_trans_fam_I. IPR004163. CoA_transf_BS. [Graphical view]
PANTHER	PTHR13707. PTHR13707. 1 hit.
Pfam	PF01144. CoA_trans. 1 hit. [Graphical view]
SMART	SM00882. CoA_trans. 1 hit. [Graphical view]
TIGRFAMs	TIGR02429. pcaI_scoA_fam. 1 hit.
PROSITE	PS01273. COA_TRANSF_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCOA_MYCBO

Accession

Primary (citable) accession number: P63649
Secondary accession number(s): O06167

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program