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P63642 (ASSY_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate synthase
EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:Rv1658, MT1696
ORF Names:MTCY06H11.23
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000148616

Regions

Nucleotide binding8 – 169ATP By similarity

Sites

Binding site871Citrulline By similarity
Binding site1171ATP; via amide nitrogen By similarity
Binding site1191Aspartate By similarity
Binding site1231Aspartate By similarity
Binding site1231Citrulline By similarity
Binding site1241Aspartate By similarity
Binding site1271Citrulline By similarity
Binding site1751Citrulline By similarity
Binding site2601Citrulline By similarity
Binding site2721Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
P63642 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 7AC21C886F62584E

FASTA39843,682
        10         20         30         40         50         60 
MSERVILAYS GGLDTSVAIS WIGKETGREV VAVAIDLGQG GEHMDVIRQR ALDCGAVEAV 

        70         80         90        100        110        120 
VVDARDEFAE GYCLPTVLNN ALYMDRYPLV SAISRPLIVK HLVAAAREHG GGIVAHGCTG 

       130        140        150        160        170        180 
KGNDQVRFEV GFASLAPDLE VLAPVRDYAW TREKAIAFAE ENAIPINVTK RSPFSIDQNV 

       190        200        210        220        230        240 
WGRAVETGFL EHLWNAPTKD IYAYTEDPTI NWGVPDEVIV GFERGVPVSV DGKPVSMLAA 

       250        260        270        280        290        300 
IEELNRRAGA QGVGRLDVVE DRLVGIKSRE IYEAPGAMVL ITAHTELEHV TLERELGRFK 

       310        320        330        340        350        360 
RQTDQRWAEL VYDGLWYSPL KAALEAFVAK TQEHVSGEVR LVLHGGHIAV NGRRSAESLY 

       370        380        390 
DFNLATYDEG DSFDQSAARG FVYVHGLSSK LAARRDLR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAB06629.1.
AE000516 Genomic DNA. Translation: AAK45965.1.
AL123456 Genomic DNA. Translation: CCP44423.1.
PIRE70621.
RefSeqNP_216174.1. NC_000962.3.
NP_336151.1. NC_002755.2.
YP_006515049.1. NC_018143.1.

3D structure databases

ProteinModelPortalP63642.
SMRP63642. Positions 4-393.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv1658.

Proteomic databases

PRIDEP63642.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK45965; AAK45965; MT1696.
GeneID13316439.
885645.
924317.
KEGGmtc:MT1696.
mtu:Rv1658.
mtv:RVBD_1658.
PATRIC18125490. VBIMycTub22151_1859.

Organism-specific databases

TubercuListRv1658.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMANDQFRFE.
ProtClustDBPRK00509.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR11587. PTHR11587. 1 hit.
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_MYCTU
AccessionPrimary (citable) accession number: P63642
Secondary accession number(s): L0TA96, P94993
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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