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Protein

Glutamate racemase

Gene

murI

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton donor/acceptorUniRule annotation1
Active sitei183Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:SP_1881
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000955191 – 264Glutamate racemaseAdd BLAST264

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
orf10Q379952EBI-11615993,EBI-3990226From Streptococcus phage Cp-1.

Protein-protein interaction databases

IntActiP63640, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP63640
SMRiP63640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 11Substrate bindingUniRule annotation2
Regioni42 – 43Substrate bindingUniRule annotation2
Regioni74 – 75Substrate bindingUniRule annotation2
Regioni184 – 185Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
HOGENOMiHOG000262396
KOiK01776
OMAiVYGCTHY

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P63640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRPIGFLD SGVGGLTVVR ELMRQLPHEE IVYIGDSARA PYGPRPAEQI
60 70 80 90 100
REYTWQLVNF LLTKDVKMIV IACNTATAVV WEEIKAQLDI PVLGVILPGA
110 120 130 140 150
SAAIKSSQGG KIGVIGTPMT VQSDIYRQKI HDLDPDLQVE SLACPKFAPL
160 170 180 190 200
VESGALSTSV TKKVVYETLR PLVGKVDSLI LGCTHYPLLR PIIQNVMGPK
210 220 230 240 250
VQLIDSGAEC VRDISVLLNY FEINRGRDAG PLHHRFYTTA SSQSFAQIGE
260
EWLEKEIHVE HVEL
Length:264
Mass (Da):29,138
Last modified:October 11, 2004 - v1
Checksum:i2D73DF7BBFD853BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK75953.1
PIRiH95219
RefSeqiWP_000370376.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK75953; AAK75953; SP_1881
KEGGispn:SP_1881

Similar proteinsi

Entry informationi

Entry nameiMURI_STRPN
AccessioniPrimary (citable) accession number: P63640
Secondary accession number(s): Q97NX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health