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Protein

Glutamate racemase

Gene

murI

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton donor/acceptorUniRule annotation
Active sitei183 – 1831Proton donor/acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1889-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:SP_1881
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Glutamate racemasePRO_0000095519Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
orf10Q379952EBI-11615993,EBI-3990226From a different organism.

Protein-protein interaction databases

IntActiP63640. 1 interaction.
STRINGi170187.SpneT_02001506.

Structurei

3D structure databases

ProteinModelPortaliP63640.
SMRiP63640. Positions 1-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate bindingUniRule annotation
Regioni42 – 432Substrate bindingUniRule annotation
Regioni74 – 752Substrate bindingUniRule annotation
Regioni184 – 1852Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRPIGFLD SGVGGLTVVR ELMRQLPHEE IVYIGDSARA PYGPRPAEQI
60 70 80 90 100
REYTWQLVNF LLTKDVKMIV IACNTATAVV WEEIKAQLDI PVLGVILPGA
110 120 130 140 150
SAAIKSSQGG KIGVIGTPMT VQSDIYRQKI HDLDPDLQVE SLACPKFAPL
160 170 180 190 200
VESGALSTSV TKKVVYETLR PLVGKVDSLI LGCTHYPLLR PIIQNVMGPK
210 220 230 240 250
VQLIDSGAEC VRDISVLLNY FEINRGRDAG PLHHRFYTTA SSQSFAQIGE
260
EWLEKEIHVE HVEL
Length:264
Mass (Da):29,138
Last modified:October 11, 2004 - v1
Checksum:i2D73DF7BBFD853BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75953.1.
PIRiH95219.
RefSeqiWP_000370376.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75953; AAK75953; SP_1881.
KEGGispn:SP_1881.
PATRICi19708225. VBIStrPne105772_1955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75953.1.
PIRiH95219.
RefSeqiWP_000370376.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliP63640.
SMRiP63640. Positions 1-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63640. 1 interaction.
STRINGi170187.SpneT_02001506.

Chemistry

ChEMBLiCHEMBL3854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75953; AAK75953; SP_1881.
KEGGispn:SP_1881.
PATRICi19708225. VBIStrPne105772_1955.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSPNE170187:GHGN-1889-MONOMER.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI_STRPN
AccessioniPrimary (citable) accession number: P63640
Secondary accession number(s): Q97NX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.