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Protein

Glutamate racemase

Gene

murI

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Proton donor/acceptorUniRule annotation
Active sitei185 – 1851Proton donor/acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:Mb1373
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Glutamate racemasePRO_0000095490Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP63636.
SMRiP63636. Positions 7-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 132Substrate bindingUniRule annotation
Regioni44 – 452Substrate bindingUniRule annotation
Regioni76 – 772Substrate bindingUniRule annotation
Regioni186 – 1872Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262396.
KOiK01776.
OMAiVYGCTHY.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPLAPVGV FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP
60 70 80 90 100
EIRAHALAIG DDLVGRGVKA LVIACNSASS ACLRDARERY QVPVVEVILP
110 120 130 140 150
AVRRAVAATR NGRIGVIGTR ATITSHAYQD AFAAARDTEI TAVACPRFVD
160 170 180 190 200
FVERGVTSGR QVLGLAQGYL EPLQRAEVDT LVLGCTHYPL LSGLIQLAMG
210 220 230 240 250
ENVTLVSSAE ETAKEVVRVL TEIDLLRPHD APPATRIFEA TGDPEAFTKL
260 270
AARFLGPVLG GVQPVHPSRI H
Length:271
Mass (Da):28,643
Last modified:October 11, 2004 - v1
Checksum:i29DE3CE67A27EEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42620.1.
RefSeqiNP_855027.1. NC_002945.3.
WP_003406919.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42620; CDO42620; Mb1373.
GeneIDi1090663.
KEGGimbo:Mb1373.
PATRICi18004713. VBIMycBov88188_1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42620.1.
RefSeqiNP_855027.1. NC_002945.3.
WP_003406919.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP63636.
SMRiP63636. Positions 7-266.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42620; CDO42620; Mb1373.
GeneIDi1090663.
KEGGimbo:Mb1373.
PATRICi18004713. VBIMycBov88188_1505.

Phylogenomic databases

HOGENOMiHOG000262396.
KOiK01776.
OMAiVYGCTHY.
OrthoDBiEOG6CZQQP.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiMURI_MYCBO
AccessioniPrimary (citable) accession number: P63636
Secondary accession number(s): Q10626, X2BI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.