P63635 (MURI_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	Rv1338, MT1379
ORF Names:	MTCY130.23, MTCY02B10.02

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from direct assay. Source: MTBBASE regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Inferred from direct assay. Source: MTBBASE glutamate racemase activity Inferred from direct assay. Source: MTBBASE protein binding Inferred from physical interaction. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Glutamate racemase HAMAP MF_00258		PRO_0000095489

Sequences

	Sequence		Length	Mass (Da)
	P63635 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 29DE3CE67A27EEBA	FASTA	271	28,643
	10 20 30 40 50 60 MNSPLAPVGV FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP EIRAHALAIG 70 80 90 100 110 120 DDLVGRGVKA LVIACNSASS ACLRDARERY QVPVVEVILP AVRRAVAATR NGRIGVIGTR 130 140 150 160 170 180 ATITSHAYQD AFAAARDTEI TAVACPRFVD FVERGVTSGR QVLGLAQGYL EPLQRAEVDT 190 200 210 220 230 240 LVLGCTHYPL LSGLIQLAMG ENVTLVSSAE ETAKEVVRVL TEIDLLRPHD APPATRIFEA 250 260 270 TGDPEAFTKL AARFLGPVLG GVQPVHPSRI H

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842576 Genomic DNA. Translation: CAA98102.1. AE000516 Genomic DNA. Translation: AAK45644.1.
PIR	F70771.
RefSeq	NP_215854.1. NC_000962.2. NP_335830.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P63635.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000003791; EBMYCP00000003791; EBMYCG00000003789. EBMYCT00000070130; EBMYCP00000068189; EBMYCG00000070125.
GeneID	886866. 924662.
GenomeReviews	Gene locus MT1379 in contig AE000516_GR. Gene locus Rv1338 in contig AL123456_GR.
KEGG	mtc:MT1379. mtu:Rv1338.
PATRIC	18124806. VBIMycTub22151_1518.
TIGR	MT1379.
Organism-specific databases
TubercuList	Rv1338.
Phylogenomic databases
GeneTree	EBGT00050000016063.
HOGENOM	HBG645102.
OMA	PQEDTIY.
PhylomeDB	P63635.
ProtClustDB	PRK00865.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_MYCTU

Accession

Primary (citable) accession number: P63635
Secondary accession number(s): Q10626

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program