Reviewed,
UniProtKB/Swiss-Prot P63629 (DHOM_MYCTU)
Last modified
November 25, 2008.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homoserine dehydrogenase Short name=HDH EC=1.1.1.3 | ||||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 441 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amino acid binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 441 | 441 | Homoserine dehydrogenase | PRO_0000066702 | |||||
Regions | |||||||||
| Domain | 355 – 433 | 79 | ACT | ||||||
| Nucleotide binding | 13 – 20 | 8 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 207 | 1 | Proton donor Potential | ||||||
| Binding site | 107 | 1 | NADP By similarity | ||||||
| Binding site | 192 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| BX842576 Genomic DNA. Translation: CAA97759.1. AE000516 Genomic DNA. Translation: AAK45595.1. | |
| PIR | B70773. |
| RefSeq | NP_215810.1. NP_335781.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 886962. 924737. |
| GenomeReviews | Gene locus MT1333 in contig AE000516_GR. Gene locus Rv1294 in contig AL123456_GR. |
| KEGG | mtc:MT1333. mtu:Rv1294. |
| TIGR | MT1333. |
Organism-specific databases | |
| TubercuList | Rv1294. |
Phylogenomic databases | |
| HOGENOM | P63629. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR005106. Asp/hSer_DHase_NAD-bd. IPR016204. hSer_DHase. IPR001342. hSer_DHase_cat. [Graphical view] |
| Pfam | PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF000098. Homoser_dehydrog. 1 hit. |
| PROSITE | PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHOM_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P63629 Secondary accession number(s): Q10601 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


