P63629 (DHOM_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Homoserine dehydrogenase Short name=HDH EC=1.1.1.3 | ||||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 441 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | growth Inferred from mutant phenotype. Source: MTBBASE isoleucine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | plasma membrane Inferred from direct assay. Source: MTBBASE |
| Molecular function | NADP binding Inferred from electronic annotation. Source: InterPro amino acid bindingInferred from electronic annotation. Source: InterPro homoserine dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 441 | 441 | Homoserine dehydrogenase | PRO_0000066702 | |||||
Regions | |||||||||
| Domain | 355 – 433 | 79 | ACT | ||||||
| Nucleotide binding | 13 – 20 | 8 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 207 | 1 | Proton donor Potential | ||||||
| Binding site | 107 | 1 | NADP By similarity | ||||||
| Binding site | 192 | 1 | Substrate By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842576 Genomic DNA. Translation: CAA97759.1. AE000516 Genomic DNA. Translation: AAK45595.1. |
| PIR | B70773. |
| RefSeq | NP_215810.1. NC_000962.2. NP_335781.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P63629. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000001792; EBMYCP00000001792; EBMYCG00000001790. EBMYCT00000072024; EBMYCP00000070083; EBMYCG00000072019. |
| GeneID | 886962. 924737. |
| GenomeReviews | Gene locus MT1333 in contig AE000516_GR. Gene locus Rv1294 in contig AL123456_GR. |
| KEGG | mtc:MT1333. mtu:Rv1294. |
| PATRIC | 18124696. VBIMycTub22151_1466. |
| TIGR | MT1333. |
Organism-specific databases | |
| TubercuList | Rv1294. |
Phylogenomic databases | |
| GeneTree | EBGT00050000016352. |
| HOGENOM | HBG527379. |
| OMA | VHPAMIP. |
| PhylomeDB | P63629. |
| ProtClustDB | PRK06349. |
Family and domain databases | |
| InterPro | IPR002912. ACT-bd. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. HDH. IPR001342. HDH_cat. IPR019811. HDH_CS. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00003. |
| Pfam | PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF000098. Homoser_dehydrog. 1 hit. |
| PROSITE | PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHOM_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P63629 Secondary accession number(s): Q10601 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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