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P63627 (ASPG_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-asparaginase
Short name=L-ASNase
EC=3.5.1.1
Alternative name(s):
L-asparagine amidohydrolase
Gene names
Name:ansA
Ordered Locus Names:Rv1538c, MT1590
ORF Names:MTCY48.27
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-asparagine + H2O = L-aspartate + NH3.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the asparaginase 1 family.

Sequence caution

The sequence AAK45856.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA98324.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionasparaginase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Probable L-asparaginase
PRO_0000171084

Regions

Region51 – 533Substrate binding By similarity
Region84 – 852Substrate binding By similarity

Sites

Active site121O-isoaspartyl threonine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P63627 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: AEC46476F73FA340

FASTA31531,741
        10         20         30         40         50         60 
MARLTVITTG GTISTTAGPD GVLRPTHCGA TLIAGLDMDS DIEVVDLMAL DSSKLTPADW 

        70         80         90        100        110        120 
DRIGAAVQEA FRGGADGVVI THGTDTLEET ALWLDLTYAG SRPVVLTGAM LSADAPGADG 

       130        140        150        160        170        180 
PANLRDALAV AADPAARDLG VLVSFGGRVL QPLGLHKVAN PDLCGFAGES LGFTSGGVRL 

       190        200        210        220        230        240 
TRTKTRPYLG DLGAAVAPRV DIVAVYPGSD AVAMDACVAA GARAVVLEAL GSGNAGAAVI 

       250        260        270        280        290        300 
EGVRRHCRDG SDPVVIAVST RVAGARVGAG YGPGHDLVEA GAVMVPRLPP SQARVLLMAA 

       310 
LAANSPVADV IDRWG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAA98324.1. Different initiation.
AE000516 Genomic DNA. Translation: AAK45856.1. Different initiation.
PIRG70760.
RefSeqNP_216054.1. NC_000962.2.
NP_336042.1. NC_002755.2.

3D structure databases

ProteinModelPortalP63627.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002984; EBMYCP00000002984; EBMYCG00000002982.
EBMYCT00000071977; EBMYCP00000070036; EBMYCG00000071972.
GeneID886410.
924360.
GenomeReviewsGene locus MT1590 in contig AE000516_GR.
Gene locus Rv1538c in contig AL123456_GR.
KEGGmtc:MT1590.
mtu:Rv1538c.
PATRIC18125263. VBIMycTub22151_1746.
TIGRMT1590.

Organism-specific databases

TubercuListRv1538c.

Phylogenomic databases

GeneTreeEBGT00050000016418.
HOGENOMHBG497495.
OMALAMVAMT.
PhylomeDBP63627.
ProtClustDBCLSK791234.

Family and domain databases

InterProIPR006034. Asparaginase/glutaminase.
IPR020827. Asparaginase/glutaminase_CS.
[Graphical view]
KOK01424.
PANTHERPTHR11707. Asp/Glutamnse. 1 hit.
PfamPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSPR00139. ASNGLNASE.
SMARTSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMSSF53774. Asp/Glutamnse. 1 hit.
PROSITEPS00144. ASN_GLN_ASE_1. 1 hit.
PS00917. ASN_GLN_ASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASPG_MYCTU
AccessionPrimary (citable) accession number: P63627
Secondary accession number(s): Q10759
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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