P63622 (ARSC_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative arsenate reductase
EC=1.20.4.1

Gene names

Name:	arsC
Ordered Locus Names:	NMB0005

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)] Potential.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Putative arsenate reductase		PRO_0000162542

Sequences

	Sequence		Length	Mass (Da)
	P63622 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: C834075A7941EBE5	FASTA	117	12,869
	10 20 30 40 50 60 MPEIKIFHNP RCSKSRAALS LLEERGIAAE VVKYLDTPPD LSELKDIFNK LGLASARGMM 70 80 90 100 110 RVKDDLYKEL GLDNPNLDND ALLRAIADHP ALLERPIVLA NGKAAVGRPL ENIEAVL

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF40484.1.
PIR	C81247.
RefSeq	NP_273071.1. NC_003112.2.
3D structure databases
ProteinModelPortal	P63622.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000009106; EBNEIP00000008726; EBNEIG00000009106.
GeneID	902107.
GenomeReviews	Gene locus NMB0005 in contig AE002098_GR.
KEGG	nme:NMB0005.
PATRIC	20354937. VBINeiMen85645_0005.
TIGR	NMB0005.
Phylogenomic databases
GeneTree	EBGT00050000021443.
HOGENOM	HBG734370.
OMA	APTIVRY.
ProtClustDB	CLSK877347.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0005-MONOMER.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00537.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00014. ArsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_NEIMB

Accession

Primary (citable) accession number: P63622
Secondary accession number(s): Q9JQU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program