Reviewed, UniProtKB/Swiss-Prot P63621 (ARSC_NEIMA)

Names and origin

Protein names

Recommended name:
    Putative arsenate reductase
    EC=1.20.4.1

Gene names

Name:	arsC
Ordered Locus Names:	NMA0252

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)] Potential.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the arsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to arsenic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Putative arsenate reductase		PRO_0000162541

Sequences

	Sequence		Length	Mass (Da)
	P63621-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: C834075A7941EBE5	FASTA	117	12,869
	10 20 30 40 50 60 MPEIKIFHNP RCSKSRAALS LLEERGIAAE VVKYLDTPPD LSELKDIFNK LGLASARGMM 70 80 90 100 110 RVKDDLYKEL GLDNPNLDND ALLRAIADHP ALLERPIVLA NGKAAVGRPL ENIEAVL

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL157959 Genomic DNA. Translation: CAM07558.1.
RefSeq	YP_002341786.1.
3D structure databases
HSSP	HSSP built from PDB template 1J9B based on UniProtKB P08692.
ModBase	Search...
Genome annotation databases
GeneID	906261.
GenomeReviews	Gene locus NMA0252 in contig AL157959_GR.
KEGG	nma:NMA0252.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P63621.
OMA	P63621. VIYHNPR.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA0252-MON.
BRENDA	1.20.4.1. 292829.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00014. arsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_NEIMA

Accession

Primary (citable) accession number: P63621
Secondary accession number(s): A1IP98, Q9JQU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)