P63612 (AROC_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Synonyms:	aroF
Ordered Locus Names:	Mb2569c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP-Rule MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP-Rule MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Chorismate synthase HAMAP-Rule MF_00300		PRO_0000140612

Sequences

	Sequence		Length	Mass (Da)
	P63612 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 6A3C14761261ADEF	FASTA	401	41,792
	10 20 30 40 50 60 MLRWITAGES HGRALVAVVE GMVAGVHVTS ADIADQLARR RLGYGRGARM TFERDAVTVL 70 80 90 100 110 120 SGIRHGSTLG GPIAIEIGNT EWPKWETVMA ADPVDPAELA DVARNAPLTR PRPGHADYAG 130 140 150 160 170 180 MLKYGFDDAR PVLERASARE TAARVAAGTV ARAFLRQALG VEVLSHVISI GASAPYEGPP 190 200 210 220 230 240 PRAEDLPAID ASPVRAYDKA AEADMIAQIE AAKKDGDTLG GVVEAVALGL PVGLGSFTSG 250 260 270 280 290 300 DHRLDSQLAA AVMGIQAIKG VEIGDGFQTA RRRGSRAHDE MYPGPDGVVR STNRAGGLEG 310 320 330 340 350 360 GMTNGQPLRV RAAMKPISTV PRALATVDLA TGDEAVAIHQ RSDVCAVPAA GVVVETMVAL 370 380 390 400 VLARAALEKF GGDSLAETQR NIAAYQRSVA DREAPAARVS G

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248343 Genomic DNA. Translation: CAD94754.1.
RefSeq	NP_856215.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63612.
SMR	P63612. Positions 1-392.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb2569c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD94754; CAD94754; Mb2569c.
GeneID	1090919.
KEGG	mbo:Mb2569c.
PATRIC	18007377. VBIMycBov88188_2826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HOG000060334.
KO	K01736.
OMA	SQVHDEI.
ProtClustDB	PRK05382.
Enzyme and pathway databases
UniPathway	UPA00053; UER00090.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth.
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. PTHR21085. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_MYCBO

Accession

Primary (citable) accession number: P63612
Secondary accession number(s): P95013

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program