ID   AROC_BRUSU              Reviewed;         364 AA.
AC   P63608; Q8G299; Q8YFL4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-NOV-2009, entry version 29.
DE   RecName: Full=Chorismate synthase;
DE            EC=4.2.3.5;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
GN   Name=aroC; OrderedLocusNames=BR0428;
OS   Brucella suis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=29461;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330 / Biovar 1;
RX   MEDLINE=22247741; PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A.,
RA   Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O.,
RA   Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M.,
RA   Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between
RT   animal and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
CC   -!- CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate =
CC       chorismate + phosphate.
CC   -!- COFACTOR: Reduced flavin (By similarity).
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 7/7.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the chorismate synthase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014291; AAN29371.1; -; Genomic_DNA.
DR   RefSeq; NP_697456.1; -.
DR   GeneID; 1166089; -.
DR   GenomeReviews; AE014291_GR; BR0428.
DR   KEGG; bms:BR0428; -.
DR   TIGR; BR0428; -.
DR   HOGENOM; P63608; -.
DR   OMA; SRFTTQR; -.
DR   BioCyc; BSUI204722:BR_0428-MON; -.
DR   BRENDA; 4.2.3.5; 281610.
DR   GO; GO:0004107; F:chorismate synthase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00300; -; 1.
DR   InterPro; IPR000453; Chorismate_synth.
DR   InterPro; IPR020541; Chorismate_synthase_CS.
DR   PANTHER; PTHR21085; Chorismate_synth; 1.
DR   Pfam; PF01264; Chorismate_synt; 1.
DR   PIRSF; PIRSF001456; Chorismate_synth; 1.
DR   ProDom; PD002941; Chorismate_synth; 1.
DR   TIGRFAMs; TIGR00033; aroC; 1.
DR   PROSITE; PS00787; CHORISMATE_SYNTHASE_1; 1.
DR   PROSITE; PS00788; CHORISMATE_SYNTHASE_2; 1.
DR   PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase.
FT   CHAIN         1    364       Chorismate synthase.
FT                                /FTId=PRO_0000140562.
SQ   SEQUENCE   364 AA;  38988 MW;  95F83B4FD5230C0E CRC64;
     MSHNSFGHLF RVTTWGESHG LALGCVVDGC PPGITFTEAE IQSFLDKRKP GQSKYTTQRR
     EPDQVRVLSG VLLGEDGVTM TTTGTPISMM IENTDQRSKD YGEIARQYRP GHADYAYDVK
     YGIRDYRGGG RSSARETAAR VAAGAIARKV VPGLEVRGAL VSIGAHDIDR SRWNWAEVDN
     NPFFTPDAGS VEVFADYLDG IRKNGSSVGA IIEIVAEGVP AGIGAPIYGK LDQDIASYLM
     SINAVKGVEI GNGFEAARLT GEENADEMRM GNDGKPIFLS NHAGGVLGGI ATGAPVVARF
     AVKPTSSILT PRRSIDKDGN EVDVMTRGRH DPCVGIRAVP IGEAMVACAI ADHYLRHRGQ
     TGRV
//