P63589 (AROD_STRR6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	spr1235

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138817
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	143	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63589 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 1829E189C5BAEFB9	FASTA	225	25,719
	10 20 30 40 50 60 MKLIVSVMPR SLEEAQALDA TRYLDADIIE WRADYLPKEA ILQVAPAIFE KFAGRELVFT 70 80 90 100 110 120 LRTRSEGGEI DLSPEEYIHL IKEVAQLYQP DYIDFEYYSY KDVFEEMLDF PNLVLSYHNF 130 140 150 160 170 180 QETPENMMEI LSELTILNPK LVKVAVMAHT EQDVLDLMNY TRGFKTLNPE QEYVTISMGK 190 200 210 220 VGKVSRITAD VTGSSWSFAS LDEVSAPGQI SLASMKKIRE ILDEA

References

[1]

"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007317 Genomic DNA. Translation: AAL00039.1.
PIR	B98026.
RefSeq	NP_358828.1. NC_003098.1.
3D structure databases
ProteinModelPortal	P63589.
SMR	P63589. Positions 1-223.
ModBase	Search...
Protein-protein interaction databases
STRING	P63589.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000015820; EBSTRP00000015216; EBSTRG00000015820.
GeneID	934452.
GenomeReviews	Gene locus spr1235 in contig AE007317_GR.
KEGG	spr:spr1235.
PATRIC	19702452. VBIStrPne107296_1341.
Phylogenomic databases
eggNOG	COG0710.
GeneTree	EBGT00050000027890.
HOGENOM	HBG732926.
OMA	VARRTVI.
PhylomeDB	P63589.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	SPNE171101:SPR1235-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STRR6

Accession

Primary (citable) accession number: P63589
Secondary accession number(s): Q97Q54

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program