P63540 (END3_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 55.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Endonuclease III EC=4.2.99.18 Alternative name(s): DNA-(apurinic or apyrimidinic site) lyase | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 245 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site By similarity. |
| Catalytic activity | The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
| Cofactor | Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand By similarity. |
| Sequence similarities | Belongs to the Nth/MutY family. |
| Sequence caution | The sequence AAK48142.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 245 | 245 | Endonuclease III | PRO_0000102219 | |||||
Sites | |||||||||
| Metal binding | 198 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 205 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 208 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 214 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842583 Genomic DNA. Translation: CAA17996.2. AE000516 Genomic DNA. Translation: AAK48142.1. Different initiation. |
| PIR | C70790. |
| RefSeq | NP_218191.2. NC_000962.2. NP_338328.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P63540. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000000148; EBMYCP00000000148; EBMYCG00000000148. EBMYCT00000071122; EBMYCP00000069181; EBMYCG00000071117. |
| GeneID | 885058. 926474. |
| GenomeReviews | Gene locus MT3775 in contig AE000516_GR. Gene locus Rv3674c in contig AL123456_GR. |
| KEGG | mtc:MT3775. mtu:Rv3674c. |
| PATRIC | 18130064. VBIMycTub22151_4125. |
| TIGR | MT3775. |
Organism-specific databases | |
| TubercuList | Rv3674c. |
Phylogenomic databases | |
| GeneTree | EBGT00050000016637. |
| HOGENOM | HBG464473. |
| OMA | EVPQTRE. |
| PhylomeDB | P63540. |
| ProtClustDB | CLSK799395. |
Family and domain databases | |
| InterPro | IPR011257. DNA_glycosylase. IPR004036. Endonuclease-III_CS2. IPR005759. Endonuclease-III_Nth. IPR004035. Endouclease-III_FeS-bd_BS. IPR003651. Endouclease3_FeS-loop_motif. IPR003265. HhH-GPD_domain. IPR000445. HhH_motif. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR023170. HTH_base_excis_C. [Graphical view] |
| Gene3D | G3DSA:1.10.340.30. DNA_glycosylase. 1 hit. G3DSA:1.10.1670.10. HTH_base_excis_C. 1 hit. |
| KO | K10773. |
| Pfam | PF10576. EndIII_4Fe-2S. 1 hit. PF00633. HHH. 1 hit. PF00730. HhH-GPD. 1 hit. [Graphical view] |
| SMART | SM00478. ENDO3c. 1 hit. SM00525. FES. 1 hit. SM00278. HhH1. 1 hit. [Graphical view] |
| SUPFAM | SSF48150. DNA_glycsylse. 1 hit. |
| TIGRFAMs | TIGR01083. Nth. 1 hit. |
| PROSITE | PS00764. ENDONUCLEASE_III_1. 1 hit. PS01155. ENDONUCLEASE_III_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | END3_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P63540 Secondary accession number(s): O69642 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with