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P63522

- LCFA_SALTI

UniProt

P63522 - LCFA_SALTI

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Protein
Long-chain-fatty-acid--CoA ligase
Gene
fadD, STY1948, t1059
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 22412ATP Inferred
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:STY1948, t1059
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Membrane; Peripheral membrane protein Reviewed prediction
Note: Partially membrane-associated Reviewed prediction.

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Long-chain-fatty-acid--CoA ligase
PRO_0000193128Add
BLAST

Proteomic databases

PRIDEiP63522.

Interactioni

Subunit structurei

Homodimer Inferred.

Protein-protein interaction databases

STRINGi220341.STY1948.

Structurei

3D structure databases

ProteinModelPortaliP63522.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000229983.
KOiK01897.
OMAiVATRWHE.
OrthoDBiEOG6MH5BV.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63522-1 [UniParc]FASTAAdd to Basket

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MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT    50
FRKLEERSRA FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI 100
VVNVNPLYTP RELEHQLNDS GAAAIIIVSN FAHTLEKVVE KTSVQHVILT 150
RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL PDAISFRSAL QHGYRMQYVK 200
PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA TYGPLLHPGK 250
ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF 300
TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG 350
QYLLEGYGLT ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA 400
PGEAGELCVK GPQVMLGYWQ RPDATDEIIK DGWLHTGDIA VMDEDGFLRI 450
VDRKKDMILV SGFNVYPNEI EDVVMQHSGV QEVAAVGVPS GSSGEAVKLF 500
VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN VGKILRRELR 550
DEARGKVDNK A 561
Length:561
Mass (Da):62,223
Last modified:October 11, 2004 - v1
Checksum:i4000B2948FE38D15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD05501.1.
AE014613 Genomic DNA. Translation: AAO68725.1.
RefSeqiNP_456325.1. NC_003198.1.
NP_804876.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68725; AAO68725; t1059.
CAD05501; CAD05501; CAD05501.
GeneIDi1248301.
KEGGisty:STY1948.
PATRICi18541813. VBISalEnt120419_1965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD05501.1 .
AE014613 Genomic DNA. Translation: AAO68725.1 .
RefSeqi NP_456325.1. NC_003198.1.
NP_804876.1. NC_004631.1.

3D structure databases

ProteinModelPortali P63522.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY1948.

Proteomic databases

PRIDEi P63522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68725 ; AAO68725 ; t1059 .
CAD05501 ; CAD05501 ; CAD05501 .
GeneIDi 1248301.
KEGGi sty:STY1948.
PATRICi 18541813. VBISalEnt120419_1965.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000229983.
KOi K01897.
OMAi VATRWHE.
OrthoDBi EOG6MH5BV.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiLCFA_SALTI
AccessioniPrimary (citable) accession number: P63522
Secondary accession number(s): Q8XGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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