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P63521

- LCFA_SALTY

UniProt

P63521 - LCFA_SALTY

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Protein

Long-chain-fatty-acid--CoA ligase

Gene
fadD, STM1818
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 22412ATP InferredAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1826-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:STM1818
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Membrane; Peripheral membrane protein Reviewed prediction
Note: Partially membrane-associated Reviewed prediction.

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Long-chain-fatty-acid--CoA ligasePRO_0000193129Add
BLAST

Proteomic databases

PaxDbiP63521.
PRIDEiP63521.

Interactioni

Subunit structurei

Homodimer Inferred.

Protein-protein interaction databases

STRINGi99287.STM1818.

Structurei

3D structure databases

ProteinModelPortaliP63521.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000229983.
KOiK01897.
OMAiVATRWHE.
OrthoDBiEOG6MH5BV.
PhylomeDBiP63521.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63521-1 [UniParc]FASTAAdd to Basket

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MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT    50
FRKLEERSRA FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI 100
VVNVNPLYTP RELEHQLNDS GAAAIIIVSN FAHTLEKVVE KTSVQHVILT 150
RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL PDAISFRSAL QHGYRMQYVK 200
PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA TYGPLLHPGK 250
ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF 300
TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG 350
QYLLEGYGLT ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA 400
PGEAGELCVK GPQVMLGYWQ RPDATDEIIK DGWLHTGDIA VMDEDGFLRI 450
VDRKKDMILV SGFNVYPNEI EDVVMQHSGV QEVAAVGVPS GSSGEAVKLF 500
VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN VGKILRRELR 550
DEARGKVDNK A 561
Length:561
Mass (Da):62,223
Last modified:October 11, 2004 - v1
Checksum:i4000B2948FE38D15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20733.1.
RefSeqiNP_460774.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20733; AAL20733; STM1818.
GeneIDi1253337.
KEGGistm:STM1818.
PATRICi32382159. VBISalEnt20916_1918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20733.1 .
RefSeqi NP_460774.1. NC_003197.1.

3D structure databases

ProteinModelPortali P63521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1818.

Proteomic databases

PaxDbi P63521.
PRIDEi P63521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20733 ; AAL20733 ; STM1818 .
GeneIDi 1253337.
KEGGi stm:STM1818.
PATRICi 32382159. VBISalEnt20916_1918.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000229983.
KOi K01897.
OMAi VATRWHE.
OrthoDBi EOG6MH5BV.
PhylomeDBi P63521.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1826-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiLCFA_SALTY
AccessioniPrimary (citable) accession number: P63521
Secondary accession number(s): Q8XGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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