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P63521 (LCFA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase

EC=6.2.1.3
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene names
Name:fadD
Ordered Locus Names:STM1818
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subunit structure

Homodimer Probable.

Subcellular location

Membrane; Peripheral membrane protein Potential. Note: Partially membrane-associated Potential.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Long-chain-fatty-acid--CoA ligase
PRO_0000193129

Regions

Nucleotide binding213 – 22412ATP Probable

Sequences

Sequence LengthMass (Da)Tools
P63521 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4000B2948FE38D15

FASTA56162,223
        10         20         30         40         50         60 
MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT FRKLEERSRA 

        70         80         90        100        110        120 
FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI VVNVNPLYTP RELEHQLNDS 

       130        140        150        160        170        180 
GAAAIIIVSN FAHTLEKVVE KTSVQHVILT RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL 

       190        200        210        220        230        240 
PDAISFRSAL QHGYRMQYVK PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA 

       250        260        270        280        290        300 
TYGPLLHPGK ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF 

       310        320        330        340        350        360 
TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG QYLLEGYGLT 

       370        380        390        400        410        420 
ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA PGEAGELCVK GPQVMLGYWQ 

       430        440        450        460        470        480 
RPDATDEIIK DGWLHTGDIA VMDEDGFLRI VDRKKDMILV SGFNVYPNEI EDVVMQHSGV 

       490        500        510        520        530        540 
QEVAAVGVPS GSSGEAVKLF VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN 

       550        560 
VGKILRRELR DEARGKVDNK A 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL20733.1.
RefSeqNP_460774.1. NC_003197.1.

3D structure databases

ProteinModelPortalP63521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1818.

Proteomic databases

PaxDbP63521.
PRIDEP63521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20733; AAL20733; STM1818.
GeneID1253337.
KEGGstm:STM1818.
PATRIC32382159. VBISalEnt20916_1918.

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000229983.
KOK01897.
OMANIIEGYG.
OrthoDBEOG6MH5BV.
ProtClustDBPRK08974.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1826-MONOMER.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCFA_SALTY
AccessionPrimary (citable) accession number: P63521
Secondary accession number(s): Q8XGG8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families