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P63521

- LCFA_SALTY

UniProt

P63521 - LCFA_SALTY

Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 22412ATPCuratedAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1826-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase
    Gene namesi
    Name:fadD
    Ordered Locus Names:STM1818
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Membrane Curated; Peripheral membrane protein Curated
    Note: Partially membrane-associated.Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Long-chain-fatty-acid--CoA ligasePRO_0000193129Add
    BLAST

    Proteomic databases

    PaxDbiP63521.
    PRIDEiP63521.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi99287.STM1818.

    Structurei

    3D structure databases

    ProteinModelPortaliP63521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000229983.
    KOiK01897.
    OMAiVATRWHE.
    OrthoDBiEOG6MH5BV.
    PhylomeDBiP63521.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63521-1 [UniParc]FASTAAdd to Basket

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    MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT    50
    FRKLEERSRA FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI 100
    VVNVNPLYTP RELEHQLNDS GAAAIIIVSN FAHTLEKVVE KTSVQHVILT 150
    RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL PDAISFRSAL QHGYRMQYVK 200
    PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA TYGPLLHPGK 250
    ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF 300
    TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG 350
    QYLLEGYGLT ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA 400
    PGEAGELCVK GPQVMLGYWQ RPDATDEIIK DGWLHTGDIA VMDEDGFLRI 450
    VDRKKDMILV SGFNVYPNEI EDVVMQHSGV QEVAAVGVPS GSSGEAVKLF 500
    VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN VGKILRRELR 550
    DEARGKVDNK A 561
    Length:561
    Mass (Da):62,223
    Last modified:October 11, 2004 - v1
    Checksum:i4000B2948FE38D15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20733.1.
    RefSeqiNP_460774.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20733; AAL20733; STM1818.
    GeneIDi1253337.
    KEGGistm:STM1818.
    PATRICi32382159. VBISalEnt20916_1918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20733.1 .
    RefSeqi NP_460774.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P63521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1818.

    Proteomic databases

    PaxDbi P63521.
    PRIDEi P63521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20733 ; AAL20733 ; STM1818 .
    GeneIDi 1253337.
    KEGGi stm:STM1818.
    PATRICi 32382159. VBISalEnt20916_1918.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000229983.
    KOi K01897.
    OMAi VATRWHE.
    OrthoDBi EOG6MH5BV.
    PhylomeDBi P63521.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1826-MONOMER.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiLCFA_SALTY
    AccessioniPrimary (citable) accession number: P63521
    Secondary accession number(s): Q8XGG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3