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P63521

- LCFA_SALTY

UniProt

P63521 - LCFA_SALTY

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Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 22412ATPCuratedAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1826-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:STM1818
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Membrane Curated; Peripheral membrane protein Curated
Note: Partially membrane-associated.Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Long-chain-fatty-acid--CoA ligasePRO_0000193129Add
BLAST

Proteomic databases

PaxDbiP63521.
PRIDEiP63521.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi99287.STM1818.

Structurei

3D structure databases

ProteinModelPortaliP63521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000229983.
KOiK01897.
OMAiVATRWHE.
OrthoDBiEOG6MH5BV.
PhylomeDBiP63521.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63521-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT
60 70 80 90 100
FRKLEERSRA FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI
110 120 130 140 150
VVNVNPLYTP RELEHQLNDS GAAAIIIVSN FAHTLEKVVE KTSVQHVILT
160 170 180 190 200
RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL PDAISFRSAL QHGYRMQYVK
210 220 230 240 250
PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA TYGPLLHPGK
260 270 280 290 300
ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF
310 320 330 340 350
TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG
360 370 380 390 400
QYLLEGYGLT ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA
410 420 430 440 450
PGEAGELCVK GPQVMLGYWQ RPDATDEIIK DGWLHTGDIA VMDEDGFLRI
460 470 480 490 500
VDRKKDMILV SGFNVYPNEI EDVVMQHSGV QEVAAVGVPS GSSGEAVKLF
510 520 530 540 550
VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN VGKILRRELR
560
DEARGKVDNK A
Length:561
Mass (Da):62,223
Last modified:October 11, 2004 - v1
Checksum:i4000B2948FE38D15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20733.1.
RefSeqiNP_460774.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20733; AAL20733; STM1818.
GeneIDi1253337.
KEGGistm:STM1818.
PATRICi32382159. VBISalEnt20916_1918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20733.1 .
RefSeqi NP_460774.1. NC_003197.1.

3D structure databases

ProteinModelPortali P63521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1818.

Proteomic databases

PaxDbi P63521.
PRIDEi P63521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20733 ; AAL20733 ; STM1818 .
GeneIDi 1253337.
KEGGi stm:STM1818.
PATRICi 32382159. VBISalEnt20916_1918.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000229983.
KOi K01897.
OMAi VATRWHE.
OrthoDBi EOG6MH5BV.
PhylomeDBi P63521.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1826-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiLCFA_SALTY
AccessioniPrimary (citable) accession number: P63521
Secondary accession number(s): Q8XGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3