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Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 224ATPCuratedAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1834-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:STM1818
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931291 – 561Long-chain-fatty-acid--CoA ligaseAdd BLAST561

Proteomic databases

PaxDbiP63521
PRIDEiP63521

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi99287.STM1818

Structurei

3D structure databases

ProteinModelPortaliP63521
SMRiP63521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CEY Bacteria
COG0318 LUCA
HOGENOMiHOG000229983
KOiK01897
OMAiKTQVKHV
PhylomeDBiP63521

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P63521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVWLNRYP ADVPAEINPD RYQSLVELFE HAATRYADQP AFVNMGEVMT
60 70 80 90 100
FRKLEERSRA FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI
110 120 130 140 150
VVNVNPLYTP RELEHQLNDS GAAAIIIVSN FAHTLEKVVE KTSVQHVILT
160 170 180 190 200
RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL PDAISFRSAL QHGYRMQYVK
210 220 230 240 250
PEVVAEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVKA TYGPLLHPGK
260 270 280 290 300
ELVVTALPLY HIFALTMNCL LFIELGGQNL LITNPRDIPG LVKELAKYPF
310 320 330 340 350
TAMTGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQNV VAERWVKLTG
360 370 380 390 400
QYLLEGYGLT ECAPLVSVNP HDIDYHSGSI GLPVPSTEAK LVDDDDNEVA
410 420 430 440 450
PGEAGELCVK GPQVMLGYWQ RPDATDEIIK DGWLHTGDIA VMDEDGFLRI
460 470 480 490 500
VDRKKDMILV SGFNVYPNEI EDVVMQHSGV QEVAAVGVPS GSSGEAVKLF
510 520 530 540 550
VVKKDPALTD DALITFCRRH LTGYKVPKQV EFREELPKSN VGKILRRELR
560
DEARGKVDNK A
Length:561
Mass (Da):62,223
Last modified:October 11, 2004 - v1
Checksum:i4000B2948FE38D15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20733.1
RefSeqiNP_460774.1, NC_003197.2
WP_000758418.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20733; AAL20733; STM1818
GeneIDi1253337
KEGGistm:STM1818
PATRICifig|99287.12.peg.1918

Similar proteinsi

Entry informationi

Entry nameiLCFA_SALTY
AccessioniPrimary (citable) accession number: P63521
Secondary accession number(s): Q8XGG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health