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P63506 (GSA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:Rv0524, MT0546
ORF Names:MTCY25D10.03
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00375

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00375.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000120425

Amino acid modifications

Modified residue2971N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63506 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6DF950736EE2BFAA

FASTA46247,516
        10         20         30         40         50         60 
MGSTEQATSR VRGAARTSAQ LFEAACSVIP GGVNSPVRAF TAVGGTPRFI TEAHGCWLID 

        70         80         90        100        110        120 
ADGNRYVDLV CSWGPMILGH AHPAVVEAVA KAAARGLSFG APTPAETQLA GEIIGRVAPV 

       130        140        150        160        170        180 
ERIRLVNSGT EATMSAVRLA RGFTGRAKIV KFSGCYHGHV DALLADAGSG VATLGLCDDP 

       190        200        210        220        230        240 
QRPASPRSQS SRGLPSSPGV TGAAAADTIV LPYNDIDAVQ QTFARFGEQI AAVITEASPG 

       250        260        270        280        290        300 
NMGVVPPGPG FNAALRAITA EHGALLILDE VMTGFRVSRS GWYGIDPVPA DLFAFGKVMS 

       310        320        330        340        350        360 
GGMPAAAFGG RAEVMQRLAP LGPVYQAGTL SGNPVAVAAG LATLRAADDA VYTALDANAD 

       370        380        390        400        410        420 
RLAGLLSEAL TDAVVPHQIS RAGNMLSVFF GETPVTDFAS ARASQTWRYP AFFHAMLDAG 

       430        440        450        460 
VYPPCSAFEA WFVSAALDDA AFGRIANALP AAARAAAQER PA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000516 Genomic DNA. Translation: AAK44769.1.
AL123456 Genomic DNA. Translation: CCP43261.1.
PIRG70544.
RefSeqNP_215038.1. NC_000962.3.
NP_334955.1. NC_002755.2.
YP_006513857.1. NC_018143.1.

3D structure databases

ProteinModelPortalP63506.
SMRP63506. Positions 18-452.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv0524.

Proteomic databases

PaxDbP63506.
PRIDEP63506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK44769; AAK44769; MT0546.
GeneID13318398.
887349.
924568.
KEGGmtc:MT0546.
mtu:Rv0524.
PATRIC18122908. VBIMycTub22151_0588.

Organism-specific databases

TubercuListRv0524.

Phylogenomic databases

eggNOGCOG0001.
HOGENOMHOG000020210.
KOK01845.
OMAFNGNPIS.
ProtClustDBPRK00062.

Enzyme and pathway databases

UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF5. PTHR11986:SF5. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_MYCTU
AccessionPrimary (citable) accession number: P63506
Secondary accession number(s): L0T413, O06390
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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