P63505 (GABT_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-aminobutyrate aminotransferase
EC=2.6.1.19

Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase
EC=2.6.1.22
GABA aminotransferase
Short name=GABA-AT
Gamma-amino-N-butyrate transaminase
Short name=GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT

Gene names

Name:	gabT
Ordered Locus Names:	Mb2620

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gamma-aminobutyric acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	(S)-3-amino-2-methylpropionate transaminase activity Inferred from electronic annotation. Source: EC 4-aminobutyrate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	4-aminobutyrate aminotransferase		PRO_0000120387
Amino acid modifications
	Modified residue	294	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63505 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 9EB88A968B3D8719	FASTA	449	46,813
	10 20 30 40 50 60 MASLQQSRRL VTEIPGPASQ ALTHRRAAAV SSGVGVTLPV FVARAGGGIV EDVDGNRLID 70 80 90 100 110 120 LGSGIAVTTI GNSSPRVVDA VRTQVAEFTH TCFMVTPYEG YVAVAEQLNR ITPGSGPKRS 130 140 150 160 170 180 VLFNSGAEAV ENAVKIARSY TGKPAVVAFD HAYHGRTNLT MALTAKSMPY KSGFGPFAPE 190 200 210 220 230 240 IYRAPLSYPY RDGLLDKQLA TNGELAAARA IGVIDKQVGA NNLAALVIEP IQGEGGFIVP 250 260 270 280 290 300 AEGFLPALLD WCRKNHVVFI ADEVQTGFAR TGAMFACEHE GPDGLEPDLI CTAKGIADGL 310 320 330 340 350 360 PLSAVTGRAE IMNAPHVGGL GGTFGGNPVA CAAALATIAT IESDGLIERA RQIERLVTDR 370 380 390 400 410 420 LTTLQAVDDR IGDVRGRGAM IAVELVKSGT TEPDAGLTER LATAAHAAGV IILTCGMFGN 430 440 IIRLLPPLTI GDELLSEGLD IVCAILADL

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248343 Genomic DNA. Translation: CAD94805.1.
RefSeq	NP_856266.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63505.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000018036; EBMYCP00000017871; EBMYCG00000018031.
GeneID	1092014.
GenomeReviews	Gene locus Mb2620 in contig BX248333_GR.
KEGG	mbo:Mb2620.
PATRIC	18007489. VBIMycBov88188_2881.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015339.
HOGENOM	HBG725944.
OMA	WDKEGRR.
ProtClustDB	PRK06058.
Enzyme and pathway databases
BioCyc	MBOV233413:MB2620-MONOMER.
Family and domain databases
InterPro	IPR004632. 4NH2But_aminotransferase_bac. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K07250.
PANTHER	PTHR11986. Aminotrans_3. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00700. GABAtrnsam. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABT_MYCBO

Accession

Primary (citable) accession number: P63505
Secondary accession number(s): Q50632

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program