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P63502 (CBL_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative cystathionine beta-lyase
Short name=CBL
EC=4.4.1.8
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Gene names
Ordered Locus Names:Rv2294, MT2351
ORF Names:MTCY339.16c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily.

Sequence caution

The sequence AAK46636.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Putative cystathionine beta-lyase
PRO_0000163850

Amino acid modifications

Modified residue2371N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63502 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: AA6296F845E2622F

FASTA40744,283
        10         20         30         40         50         60 
MIPNPLEELT LEQLRSQRTS MKWRAHPADV LPLWVAEMDV KLPPTVADAL RRAIDDGDTG 

        70         80         90        100        110        120 
YPYGTEYAEA VREFACQRWQ WHDLEVSRTA IVPDVMLGIV EVLRLITDRG DPVIVNSPVY 

       130        140        150        160        170        180 
APFYAFVSHD GRRVIPAPLR GDGRIDLDAL QEAFSSARAS SGSSGNVAYL LCNPHNPTGS 

       190        200        210        220        230        240 
VHTADELRGI AERAQRFGVR VVSDEIHAPL IPSGARFTPY LSVPGAENAF ALMSASKAWN 

       250        260        270        280        290        300 
LGGLKAALAI AGREAAADLA RMPEEVGHGP SHLGVIAHTA AFRTGGNWLD ALLRGLDHNR 

       310        320        330        340        350        360 
TLLGALVDEH LPGVQYRWPQ GTYLAWLDCR ELGFDDAASD EMTEGLAVVS DLSGPARWFL 

       370        380        390        400 
DHARVALSSG HVFGIGGAGH VRINFATSRA ILIEAVSRMS RSLLERR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAB00976.1.
AE000516 Genomic DNA. Translation: AAK46636.1. Different initiation.
PIRB70733.
RefSeqNP_216810.1. NC_000962.2.
NP_336822.1. NC_002755.2.

3D structure databases

ProteinModelPortalP63502.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001934; EBMYCP00000001934; EBMYCG00000001932.
EBMYCT00000069657; EBMYCP00000067716; EBMYCG00000069652.
GeneID885868.
924071.
GenomeReviewsGene locus MT2351 in contig AE000516_GR.
Gene locus Rv2294 in contig AL123456_GR.
KEGGmtc:MT2351.
mtu:Rv2294.
PATRIC18126918. VBIMycTub22151_2569.
TIGRMT2351.

Organism-specific databases

TubercuListRv2294.

Phylogenomic databases

GeneTreeEBGT00070000032189.
HOGENOMHBG681988.
OMAAYSHGTE.
PhylomeDBP63502.
ProtClustDBCLSK872043.

Family and domain databases

InterProIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK14155.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBL_MYCTU
AccessionPrimary (citable) accession number: P63502
Secondary accession number(s): Q50672
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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