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Protein

Ureidoglycolate lyase

Gene

allA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.UniRule annotation

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation

Cofactori

Ni2+UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPurine metabolism

Enzyme and pathway databases

UniPathwayiUPA00395

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Gene namesi
Name:allAUniRule annotation
Ordered Locus Names:SF0444, S0451
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205591 – 160Ureidoglycolate lyaseAdd BLAST160

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi10 – 13Combined sources4
Turni14 – 16Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi28 – 30Combined sources3
Turni31 – 34Combined sources4
Beta strandi35 – 38Combined sources4
Beta strandi46 – 48Combined sources3
Beta strandi53 – 59Combined sources7
Beta strandi70 – 73Combined sources4
Beta strandi79 – 85Combined sources7
Beta strandi90 – 94Combined sources5
Beta strandi97 – 99Combined sources3
Helixi102 – 104Combined sources3
Beta strandi106 – 109Combined sources4
Beta strandi115 – 118Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi148 – 151Combined sources4
Beta strandi156 – 158Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSRX-ray2.80A/B1-160[»]
ProteinModelPortaliP63487
SMRiP63487
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63487

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z2U Bacteria
COG3194 LUCA
HOGENOMiHOG000256169
KOiK01483
OMAiNCDIFQF

Family and domain databases

Gene3Di2.60.120.480, 1 hit
HAMAPiMF_00616 Ureidogly_lyase, 1 hit
InterProiView protein in InterPro
IPR011051 RmlC_Cupin_sf
IPR007247 Ureidogly_lyase
IPR023525 Ureidogly_lyase_bac
IPR024060 Ureidoglycolate_lyase_dom_sf
PANTHERiPTHR21221 PTHR21221, 1 hit
PfamiView protein in Pfam
PF04115 Ureidogly_lyase, 1 hit
PIRSFiPIRSF017306 Ureidogly_hydro, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

P63487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD
60 70 80 90 100
RTLISINRAQ PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP
110 120 130 140 150
DLSTLRAFIT NGEQGVNYHR NVWHHPLFAW QRVTDFLTID RGGSDNCDVE
160
SIPEQELCFA
Length:160
Mass (Da):18,223
Last modified:October 11, 2004 - v1
Checksum:iE39014610FE93FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN42098.1
AE014073 Genomic DNA Translation: AAP15974.1
RefSeqiNP_706391.1, NC_004337.2
WP_000776388.1, NZ_NIYV01000051.1

Genome annotation databases

EnsemblBacteriaiAAN42098; AAN42098; SF0444
AAP15974; AAP15974; S0451
GeneIDi1027733
KEGGisfl:SF0444
sft:NCTC1_00458
sfx:S0451
PATRICifig|198214.7.peg.509

Similar proteinsi

Entry informationi

Entry nameiALLA_SHIFL
AccessioniPrimary (citable) accession number: P63487
Secondary accession number(s): Q8XCX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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