Ureidoglycolate hydrolase - Shigella flexneri

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Reviewed, UniProtKB/Swiss-Prot P63487 (ALLA_SHIFL)

Last modified November 3, 2009. Version 40. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Ureidoglycolate hydrolase
EC=3.5.3.19

Gene names

Name:	allA
Ordered Locus Names:	SF0444, S0451

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate By similarity.
Catalytic activity	(S)-ureidoglycolate + H₂O = glyoxylate + 2 NH₃ + CO₂. HAMAP MF_00616
Pathway	Nitrogen metabolism; (S)-allantoin degradation; glyoxylate from (S)-ureidoglycolate: step 1/1. HAMAP MF_00616
Subunit structure	Homodimer. Ref.3
Sequence similarities	Belongs to the ureidoglycolate hydrolase family.

Ontologies

Keywords
Biological process	Purine metabolism
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	allantoin catabolic process Inferred from electronic annotation. Source: InterPro purine base catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ureidoglycolate hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

160

Ureidoglycolate hydrolase HAMAP MF_00616

PRO_0000120559

Secondary structure

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160

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P63487-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E39014610FE93FC6
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160

18,223

        10         20         30         40         50         60 
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD RTLISINRAQ 

        70         80         90        100        110        120 
PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP DLSTLRAFIT NGEQGVNYHR 

       130        140        150        160 
NVWHHPLFAW QRVTDFLTID RGGSDNCDVE SIPEQELCFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.
[2]	"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.
[3]	"X-ray structure of Northeast structural genomics consortium target Sfr7." Northeast structural genomics consortium (NESG) Submitted (JAN-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), SUBUNIT.

Cross-references

Sequence databases

AE005674 Genomic DNA. Translation: AAN42098.1.
AE014073 Genomic DNA. Translation: AAP15974.1.

RefSeq

NP_706391.1.
NP_836168.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XSR	X-ray	2.80	A/B	1-160	[»]

ModBase

Genome annotation databases

GeneID

1027733.
1076890.

GenomeReviews

Gene locus SF0444 in contig AE005674_GR.
Gene locus S0451 in contig AE014073_GR.

KEGG

sfl:SF0444.
sfx:S0451.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

OMA

Enzyme and pathway databases

BioCyc

SFLE198214:AAN42098.1-MON.

BRENDA

3.5.3.19. 189495.

Family and domain databases

HAMAP

MF_00616.
[Tree]

InterPro

IPR007247. Ureidogly_hydro.
[Graphical view]

PANTHER

PTHR21221. Ureidogly_hydro. 1 hit.

Pfam

PF04115. Ureidogly_hydro. 1 hit.
[Graphical view]

PIRSF

PIRSF017306. Ureidogly_hydro. 1 hit.

ProtoNet

Entry information

Entry name

ALLA_SHIFL

Accession

Primary (citable) accession number: P63487
Secondary accession number(s): Q8XCX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents