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Protein

Ureidoglycolate lyase

Gene

allA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.UniRule annotation

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation

Cofactori

Ni2+UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

UniPathwayiUPA00395.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Gene namesi
Name:allAUniRule annotation
Ordered Locus Names:SF0444, S0451
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205591 – 160Ureidoglycolate lyaseAdd BLAST160

Proteomic databases

PaxDbiP63487.

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi198214.SF0444.

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi10 – 13Combined sources4
Turni14 – 16Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi28 – 30Combined sources3
Turni31 – 34Combined sources4
Beta strandi35 – 38Combined sources4
Beta strandi46 – 48Combined sources3
Beta strandi53 – 59Combined sources7
Beta strandi70 – 73Combined sources4
Beta strandi79 – 85Combined sources7
Beta strandi90 – 94Combined sources5
Beta strandi97 – 99Combined sources3
Helixi102 – 104Combined sources3
Beta strandi106 – 109Combined sources4
Beta strandi115 – 118Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi148 – 151Combined sources4
Beta strandi156 – 158Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSRX-ray2.80A/B1-160[»]
ProteinModelPortaliP63487.
SMRiP63487.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63487.

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z2U. Bacteria.
COG3194. LUCA.
HOGENOMiHOG000256169.
KOiK01483.
OMAiEMMERHP.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase. 1 hit.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P63487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD
60 70 80 90 100
RTLISINRAQ PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP
110 120 130 140 150
DLSTLRAFIT NGEQGVNYHR NVWHHPLFAW QRVTDFLTID RGGSDNCDVE
160
SIPEQELCFA
Length:160
Mass (Da):18,223
Last modified:October 11, 2004 - v1
Checksum:iE39014610FE93FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN42098.1.
AE014073 Genomic DNA. Translation: AAP15974.1.
RefSeqiNP_706391.1. NC_004337.2.
WP_000776388.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN42098; AAN42098; SF0444.
AAP15974; AAP15974; S0451.
GeneIDi1027733.
KEGGisfl:SF0444.
sft:NCTC1_00458.
sfx:S0451.
PATRICi18701931. VBIShiFle31049_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN42098.1.
AE014073 Genomic DNA. Translation: AAP15974.1.
RefSeqiNP_706391.1. NC_004337.2.
WP_000776388.1. NZ_LM651928.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSRX-ray2.80A/B1-160[»]
ProteinModelPortaliP63487.
SMRiP63487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF0444.

Proteomic databases

PaxDbiP63487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN42098; AAN42098; SF0444.
AAP15974; AAP15974; S0451.
GeneIDi1027733.
KEGGisfl:SF0444.
sft:NCTC1_00458.
sfx:S0451.
PATRICi18701931. VBIShiFle31049_0498.

Phylogenomic databases

eggNOGiENOG4108Z2U. Bacteria.
COG3194. LUCA.
HOGENOMiHOG000256169.
KOiK01483.
OMAiEMMERHP.

Enzyme and pathway databases

UniPathwayiUPA00395.

Miscellaneous databases

EvolutionaryTraceiP63487.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase. 1 hit.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLA_SHIFL
AccessioniPrimary (citable) accession number: P63487
Secondary accession number(s): Q8XCX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.