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Protein

Ureidoglycolate lyase

Gene

allA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.UniRule annotation

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation

Cofactori

Ni2+UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPurine metabolism

Enzyme and pathway databases

BRENDAi4.3.2.3 2026
UniPathwayiUPA00395

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Gene namesi
Name:allAUniRule annotation
Ordered Locus Names:Z0659, ECs0566
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205491 – 160Ureidoglycolate lyaseAdd BLAST160

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi155864.Z0659

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi10 – 13Combined sources4
Turni14 – 16Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi27 – 30Combined sources4
Turni31 – 34Combined sources4
Beta strandi35 – 43Combined sources9
Beta strandi46 – 48Combined sources3
Helixi49 – 51Combined sources3
Beta strandi53 – 59Combined sources7
Beta strandi67 – 73Combined sources7
Beta strandi79 – 86Combined sources8
Beta strandi90 – 94Combined sources5
Beta strandi97 – 99Combined sources3
Beta strandi106 – 109Combined sources4
Beta strandi115 – 118Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi148 – 158Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YQCX-ray1.71A/B1-160[»]
ProteinModelPortaliP63486
SMRiP63486
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63486

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z2U Bacteria
COG3194 LUCA
HOGENOMiHOG000256169
KOiK01483
OMAiNCDIFQF

Family and domain databases

Gene3Di2.60.120.480, 1 hit
HAMAPiMF_00616 Ureidogly_lyase, 1 hit
InterProiView protein in InterPro
IPR011051 RmlC_Cupin_sf
IPR007247 Ureidogly_lyase
IPR023525 Ureidogly_lyase_bac
IPR024060 Ureidoglycolate_lyase_dom_sf
PANTHERiPTHR21221 PTHR21221, 1 hit
PfamiView protein in Pfam
PF04115 Ureidogly_lyase, 1 hit
PIRSFiPIRSF017306 Ureidogly_hydro, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

P63486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD
60 70 80 90 100
RTLISINRAQ PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP
110 120 130 140 150
DLSTLRAFIT NGEQGVNYHR NVWHHPLFAW QRVTDFLTID RGGSDNCDVE
160
SIPEQELCFA
Length:160
Mass (Da):18,223
Last modified:October 11, 2004 - v1
Checksum:iE39014610FE93FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG54861.1
BA000007 Genomic DNA Translation: BAB33989.1
PIRiA85550
F90699
RefSeqiNP_308593.1, NC_002695.1
WP_000776388.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG54861; AAG54861; Z0659
BAB33989; BAB33989; BAB33989
GeneIDi915530
KEGGiece:Z0659
ecs:ECs0566
PATRICifig|386585.9.peg.674

Similar proteinsi

Entry informationi

Entry nameiALLA_ECO57
AccessioniPrimary (citable) accession number: P63486
Secondary accession number(s): Q8XCX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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