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P63483 (ALR2_STAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase 2
EC=5.1.1.1
Gene names
Name:alr2
Ordered Locus Names:SA1231
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Alanine racemase 2 HAMAP MF_01201
PRO_0000114578

Sites

Active site301Proton acceptor; specific for D-alanine By similarity
Active site2561Proton acceptor; specific for L-alanine By similarity

Amino acid modifications

Modified residue301N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63483 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1EA4213C509CF5CA

FASTA36141,396
        10         20         30         40         50         60 
MTATWSVNKK IFLQNAITVK NNQPLMAVVK NNAYHYDLEF AVTQFIHAGI DTFSTTSLRE 

        70         80         90        100        110        120 
AIQIRQLAPD ATIFLMNAVY EFDLVREHQI HMTLPSLTYY YNHKNDLAGI HVHLEFENLL 

       130        140        150        160        170        180 
HRSGFKDLNE IKEVLKDHHH NQNAKMIISG LWTHFGYADE FDVSDYNVER SQWMEIVEAL 

       190        200        210        220        230        240 
LSEGYQFDLI HAQNSASFYR EGQILLPHHT HARVGIALYG SRPYSSLNQH DIVQSLTVKA 

       250        260        270        280        290        300 
HVIQVREVQA GDYCGYSFAF EVTKNNTKLA VVDIGYGDGI LRTRAKHEAL INGKRYPIRA 

       310        320        330        340        350        360 
LMMSHMFVEV DGNVHAQDEV ILYNNDIRID EYTFKGVGAN SEQLSAMNHD SLKKEYISND 


C

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000018 Genomic DNA. Translation: BAB42491.1.
PIRG89916.
RefSeqNP_374512.1. NC_002745.2.

3D structure databases

ProteinModelPortalP63483.
ModBaseSearch...

Protein-protein interaction databases

STRINGP63483.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000000137; EBSTAP00000000137; EBSTAG00000000137.
GeneID1124070.
GenomeReviewsGene locus SA1231 in contig BA000018_GR.
KEGGsau:SA1231.
PATRIC19574712. VBIStaAur116463_1325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
GeneTreeEBGT00050000023673.
HOGENOMHBG712172.
OMAAYHYGLE.
ProtClustDBCLSK885326.

Enzyme and pathway databases

BioCycSAUR158879:SA1231-MONOMER.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01775.
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR2_STAAN
AccessionPrimary (citable) accession number: P63483
Secondary accession number(s): Q99U86
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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