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P63459

- FABD_MYCBO

UniProt

P63459 - FABD_MYCBO

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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene
fabD, Mb2267
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911 By similarity
Active sitei194 – 1941 By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:Mb2267
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Malonyl CoA-acyl carrier protein transacylasePRO_0000194217Add
BLAST

PTM databases

PhosSiteiP0805311.

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2267.

Structurei

3D structure databases

ProteinModelPortaliP63459.
SMRiP63459. Positions 1-302.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi206 – 2105Poly-Ala
Compositional biasi233 – 2364Poly-Ala

Sequence similaritiesi

Belongs to the FabD family.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036505.
KOiK00645.
OMAiMVLVRER.
OrthoDBiEOG6VB6T5.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.

Sequencei

Sequence statusi: Complete.

P63459-1 [UniParc]FASTAAdd to Basket

« Hide

MIALLAPGQG SQTEGMLSPW LQLPGAADQI AAWSKAADLD LARLGTTAST    50
EEITDTAVAQ PLIVAATLLA HQELARRCVL AGKDVIVAGH SVGEIAAYAI 100
AGVIAADDAV ALAATRGAEM AKACATEPTG MSAVLGGDET EVLSRLEQLD 150
LVPANRNAAG QIVAAGRLTA LEKLAEDPPA KARVRALGVA GAFHTEFMAP 200
ALDGFAAAAA NIATADPTAT LLSNRDGKPV TSAAAAMDTL VSQLTQPVRW 250
DLCTATLREH TVTAIVEFPP AGTLSGIAKR ELRGVPARAV KSPADLDELA 300
NL 302
Length:302
Mass (Da):30,788
Last modified:October 11, 2004 - v1
Checksum:iBB7BCD8217FC66C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43524.1.
RefSeqiNP_855916.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97120; CAD97120; Mb2267.
GeneIDi1091405.
KEGGimbo:Mb2267.
PATRICi18006686. VBIMycBov88188_2488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43524.1 .
RefSeqi NP_855916.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63459.
SMRi P63459. Positions 1-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2267.

PTM databases

PhosSitei P0805311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97120 ; CAD97120 ; Mb2267 .
GeneIDi 1091405.
KEGGi mbo:Mb2267.
PATRICi 18006686. VBIMycBov88188_2488.

Phylogenomic databases

eggNOGi COG0331.
HOGENOMi HOG000036505.
KOi K00645.
OMAi MVLVRER.
OrthoDBi EOG6VB6T5.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFABD_MYCBO
AccessioniPrimary (citable) accession number: P63459
Secondary accession number(s): Q10501, X2BK93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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