P63459 (FABD_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malonyl CoA-acyl carrier protein transacylase
Short name=MCT
EC=2.3.1.39

Gene names

Name:	fabD
Ordered Locus Names:	Mb2267

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the fabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Malonyl CoA-acyl carrier protein transacylase		PRO_0000194217
Regions
	Compositional bias	206 – 210	5	Poly-Ala
	Compositional bias	233 – 236	4	Poly-Ala
Sites
	Active site	91	1	By similarity
	Active site	194	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63459 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: BB7BCD8217FC66C8	FASTA	302	30,788
	10 20 30 40 50 60 MIALLAPGQG SQTEGMLSPW LQLPGAADQI AAWSKAADLD LARLGTTAST EEITDTAVAQ 70 80 90 100 110 120 PLIVAATLLA HQELARRCVL AGKDVIVAGH SVGEIAAYAI AGVIAADDAV ALAATRGAEM 130 140 150 160 170 180 AKACATEPTG MSAVLGGDET EVLSRLEQLD LVPANRNAAG QIVAAGRLTA LEKLAEDPPA 190 200 210 220 230 240 KARVRALGVA GAFHTEFMAP ALDGFAAAAA NIATADPTAT LLSNRDGKPV TSAAAAMDTL 250 260 270 280 290 300 VSQLTQPVRW DLCTATLREH TVTAIVEFPP AGTLSGIAKR ELRGVPARAV KSPADLDELA NL

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248341 Genomic DNA. Translation: CAD97120.1.
RefSeq	NP_855916.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63459.
SMR	P63459. Positions 1-302.
ModBase	Search...
PTM databases
PhosSite	P63459.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000016951; EBMYCP00000016786; EBMYCG00000016946.
GeneID	1091405.
GenomeReviews	Gene locus Mb2267 in contig BX248333_GR.
KEGG	mbo:Mb2267.
PATRIC	18006686. VBIMycBov88188_2488.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015146.
HOGENOM	HBG687898.
OMA	SPVRWDL.
ProtClustDB	CLSK872033.
Enzyme and pathway databases
BioCyc	MBOV233413:MB2267-MONOMER.
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR016036. Malonyl_transacylase_ACP-bd. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits.
KO	K00645.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABD_MYCBO

Accession

Primary (citable) accession number: P63459
Secondary accession number(s): Q10501

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program