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P63457 (FAB2_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2

EC=2.3.1.41
Alternative name(s):
Beta-ketoacyl-ACP synthase 2
Short name=KAS 2
Gene names
Name:kasB
Ordered Locus Names:Mb2270
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence caution

The sequence CAD97123.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4174173-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180330

Sites

Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P63457 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 239F7D19A6380F66

FASTA41744,277
        10         20         30         40         50         60 
MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV EEFDLPVRIG 

        70         80         90        100        110        120 
GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP EVDTNRLMVS IGTGLGSAEE 

       130        140        150        160        170        180 
LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA AAVGLERHAK AGVMTPVSAC ASGAEAIARA 

       190        200        210        220        230        240 
WQQIVLGEAD AAICGGVETR IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG 

       250        260        270        280        290        300 
EGGALLLIET EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL 

       310        320        330        340        350        360 
APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA VGAVESILTV 

       370        380        390        400        410 
LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN NSFGFGGHNV AIAFGRY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248341 Genomic DNA. Translation: CAD97123.1. Different initiation.
RefSeqNP_855919.1. NC_002945.3.

3D structure databases

ProteinModelPortalP63457.
SMRP63457. Positions 4-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2270.

Chemistry

BindingDBP63457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD97123; CAD97123; Mb2270.
GeneID1091410.
KEGGmbo:Mb2270.
PATRIC18006692. VBIMycBov88188_2491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0304.
HOGENOMHOG000060166.
KOK11609.
OrthoDBEOG6DG2SR.
ProtClustDBPRK07910.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFAB2_MYCBO
AccessionPrimary (citable) accession number: P63457
Secondary accession number(s): Q10525
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways