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P63457

- FAB2_MYCBO

UniProt

P63457 - FAB2_MYCBO

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

kasB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701By similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase 2
    Short name:
    KAS 2
    Gene namesi
    Name:kasB
    Ordered Locus Names:Mb2270
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4174173-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180330Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2270.

    Structurei

    3D structure databases

    ProteinModelPortaliP63457.
    SMRiP63457. Positions 4-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK11609.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P63457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV    50
    EEFDLPVRIG GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP 100
    EVDTNRLMVS IGTGLGSAEE LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA 150
    AAVGLERHAK AGVMTPVSAC ASGAEAIARA WQQIVLGEAD AAICGGVETR 200
    IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG EGGALLLIET 250
    EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL 300
    APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA 350
    VGAVESILTV LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN 400
    NSFGFGGHNV AIAFGRY 417
    Length:417
    Mass (Da):44,277
    Last modified:October 11, 2004 - v1
    Checksum:i239F7D19A6380F66
    GO

    Sequence cautioni

    The sequence CDO43527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43527.1. Different initiation.
    RefSeqiNP_855919.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD97123; CAD97123; Mb2270.
    GeneIDi1091410.
    KEGGimbo:Mb2270.
    PATRICi18006692. VBIMycBov88188_2491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43527.1 . Different initiation.
    RefSeqi NP_855919.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P63457.
    SMRi P63457. Positions 4-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2270.

    Chemistry

    BindingDBi P63457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD97123 ; CAD97123 ; Mb2270 .
    GeneIDi 1091410.
    KEGGi mbo:Mb2270.
    PATRICi 18006692. VBIMycBov88188_2491.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K11609.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiFAB2_MYCBO
    AccessioniPrimary (citable) accession number: P63457
    Secondary accession number(s): Q10525, X2BJP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3