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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

kasB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase 2
Short name:
KAS 2
Gene namesi
Name:kasB
Ordered Locus Names:Mb2270
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4174173-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180330Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2270.

Structurei

3D structure databases

ProteinModelPortaliP63457.
SMRiP63457. Positions 4-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

P63457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV
60 70 80 90 100
EEFDLPVRIG GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP
110 120 130 140 150
EVDTNRLMVS IGTGLGSAEE LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA
160 170 180 190 200
AAVGLERHAK AGVMTPVSAC ASGAEAIARA WQQIVLGEAD AAICGGVETR
210 220 230 240 250
IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG EGGALLLIET
260 270 280 290 300
EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL
310 320 330 340 350
APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA
360 370 380 390 400
VGAVESILTV LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN
410
NSFGFGGHNV AIAFGRY
Length:417
Mass (Da):44,277
Last modified:October 11, 2004 - v1
Checksum:i239F7D19A6380F66
GO

Sequence cautioni

The sequence CDO43527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43527.1. Different initiation.
RefSeqiNP_855919.1. NC_002945.3.

Genome annotation databases

GeneIDi1091410.
KEGGimbo:Mb2270.
PATRICi18006692. VBIMycBov88188_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43527.1. Different initiation.
RefSeqiNP_855919.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP63457.
SMRiP63457. Positions 4-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233413.Mb2270.

Chemistry

BindingDBiP63457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1091410.
KEGGimbo:Mb2270.
PATRICi18006692. VBIMycBov88188_2491.

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAB2_MYCBO
AccessioniPrimary (citable) accession number: P63457
Secondary accession number(s): Q10525, X2BJP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.