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P63457

- FAB2_MYCBO

UniProt

P63457 - FAB2_MYCBO

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene
kasB, Mb2270
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase 2
Short name:
KAS 2
Gene namesi
Name:kasB
Ordered Locus Names:Mb2270
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4174173-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180330Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2270.

Structurei

3D structure databases

ProteinModelPortaliP63457.
SMRiP63457. Positions 4-417.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

P63457-1 [UniParc]FASTAAdd to Basket

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MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV    50
EEFDLPVRIG GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP 100
EVDTNRLMVS IGTGLGSAEE LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA 150
AAVGLERHAK AGVMTPVSAC ASGAEAIARA WQQIVLGEAD AAICGGVETR 200
IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG EGGALLLIET 250
EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL 300
APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA 350
VGAVESILTV LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN 400
NSFGFGGHNV AIAFGRY 417
Length:417
Mass (Da):44,277
Last modified:October 11, 2004 - v1
Checksum:i239F7D19A6380F66
GO

Sequence cautioni

The sequence CDO43527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43527.1. Different initiation.
RefSeqiNP_855919.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97123; CAD97123; Mb2270.
GeneIDi1091410.
KEGGimbo:Mb2270.
PATRICi18006692. VBIMycBov88188_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43527.1 . Different initiation.
RefSeqi NP_855919.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63457.
SMRi P63457. Positions 4-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2270.

Chemistry

BindingDBi P63457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97123 ; CAD97123 ; Mb2270 .
GeneIDi 1091410.
KEGGi mbo:Mb2270.
PATRICi 18006692. VBIMycBov88188_2491.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K11609.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAB2_MYCBO
AccessioniPrimary (citable) accession number: P63457
Secondary accession number(s): Q10525, X2BJP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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