Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P63456 (FAB2_MYCTU)

Last modified November 3, 2009. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2
    EC=2.3.1.41
Alternative name(s):
    Beta-ketoacyl-ACP synthase 2
      Short name=KAS 2
Gene names
Name: kasB
Ordered Locus Names: Rv2246, MT2306
ORF Names: MTCY427.27
OrganismMycobacterium tuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Hide | Top

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Hide | Top

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4174173-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180334

Sites

Active site1701 By similarity

Secondary structure

1 ................................................................. 417
Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P63456-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 239F7D19A6380F66

FASTA41744,277
        10         20         30         40         50         60 
MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV EEFDLPVRIG 

        70         80         90        100        110        120 
GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP EVDTNRLMVS IGTGLGSAEE 

       130        140        150        160        170        180 
LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA AAVGLERHAK AGVMTPVSAC ASGAEAIARA 

       190        200        210        220        230        240 
WQQIVLGEAD AAICGGVETR IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG 

       250        260        270        280        290        300 
EGGALLLIET EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL 

       310        320        330        340        350        360 
APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA VGAVESILTV 

       370        380        390        400        410 
LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN NSFGFGGHNV AIAFGRY

« Hide

Hide | Top

Cross-references

Sequence databases

BX842579 Genomic DNA. Translation: CAA94642.1. Different initiation.
AE000516 Genomic DNA. Translation: AAK46590.1.
PIRB70779.
RefSeqNP_216762.1.
NP_336776.2.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2GP6X-ray2.40A/B5-417[»]
ModBaseSearch...

PTM databases

PhosSiteP63456.

Genome annotation databases

GeneID887539.
924119.
GenomeReviewsGene locus MT2306 in contig AE000516_GR.
Gene locus Rv2246 in contig AL123456_GR.
KEGGmtc:MT2306.
mtu:Rv2246.
TIGRMT2306.

Organism-specific databases

TubercuListRv2246.

Phylogenomic databases

HOGENOMP63456.
OMAATKSATG.

Enzyme and pathway databases

BRENDA2.3.1.41. 809.

Family and domain databases

InterProIPR000794. Beta-ketoacyl_synthase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHERPTHR11712. Ketoacyl_synth. 1 hit.
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PROSITEPS00606. B_KETOACYL_SYNTHASE. False negative.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameFAB2_MYCTU
AccessionPrimary (citable) accession number: P63456
Secondary accession number(s): Q10525
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents