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P63454 (FAB1_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1
EC=2.3.1.41
Alternative name(s):
Beta-ketoacyl-ACP synthase 1
Short name=KAS 1
Gene names
Name:kasA
Ordered Locus Names:Rv2245, MT2305
ORF Names:MTCY427.26
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180333

Sites

Active site1711 By similarity

Secondary structure

1 .............................................................. 416
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P63454 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: D2187BE2F0B56C7F

FASTA41643,316
        10         20         30         40         50         60 
MSQPSTANGG FPSVVVTAVT ATTSISPDIE STWKGLLAGE SGIHALEDEF VTKWDLAVKI 

        70         80         90        100        110        120 
GGHLKDPVDS HMGRLDMRRM SYVQRMGKLL GGQLWESAGS PEVDPDRFAV VVGTGLGGAE 

       130        140        150        160        170        180 
RIVESYDLMN AGGPRKVSPL AVQMIMPNGA AAVIGLQLGA RAGVMTPVSA CSSGSEAIAH 

       190        200        210        220        230        240 
AWRQIVMGDA DVAVCGGVEG PIEALPIAAF SMMRAMSTRN DEPERASRPF DKDRDGFVFG 

       250        260        270        280        290        300 
EAGALMLIET EEHAKARGAK PLARLLGAGI TSDAFHMVAP AADGVRAGRA MTRSLELAGL 

       310        320        330        340        350        360 
SPADIDHVNA HGTATPIGDA AEANAIRVAG CDQAAVYAPK SALGHSIGAV GALESVLTVL 

       370        380        390        400        410 
TLRDGVIPPT LNYETPDPEI DLDVVAGEPR YGDYRYAVNN SFGFGGHNVA LAFGRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAA94641.1.
AE000516 Genomic DNA. Translation: AAK46589.1.
PIRA70779.
RefSeqNP_216761.1. NC_000962.2.
NP_336775.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WGDX-ray2.01A1-416[»]
2WGEX-ray1.80A1-416[»]
2WGFX-ray2.15A/B/C/D/E/F/G/H1-416[»]
2WGGX-ray2.00A/B/C/D/E/F/G/H1-416[»]
ProteinModelPortalP63454.
SMRP63454. Positions 10-416.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-13139N.

PTM databases

PhosSiteP63454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001165; EBMYCP00000001165; EBMYCG00000001165.
EBMYCT00000069958; EBMYCP00000068017; EBMYCG00000069953.
GeneID887269.
924120.
GenomeReviewsGene locus MT2305 in contig AE000516_GR.
Gene locus Rv2245 in contig AL123456_GR.
KEGGmtc:MT2305.
mtu:Rv2245.
PATRIC18126817. VBIMycTub22151_2519.
TIGRMT2305.

Organism-specific databases

TubercuListRv2245.

Phylogenomic databases

GeneTreeEBGT00050000015144.
HOGENOMHBG757733.
OMARIGGHLK.
PhylomeDBP63454.
ProtClustDBPRK07314.

Family and domain databases

InterProIPR000794. Beta-ketoacyl_synthase.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK11609.
PANTHERPTHR11712. Ketoacyl_synth. 1 hit.
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 2 hits.
PROSITEPS00606. B_KETOACYL_SYNTHASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAB1_MYCTU
AccessionPrimary (citable) accession number: P63454
Secondary accession number(s): Q10524
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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