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Protein

Acyl carrier protein AcpXL

Gene

acpXL

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).By similarity

Pathwayi: KDO(2)-lipid A biosynthesis

This protein is involved in the pathway KDO(2)-lipid A biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway KDO(2)-lipid A biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein AcpXL
Gene namesi
Name:acpXL
Ordered Locus Names:BMEI1111
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Acyl carrier protein AcpXLPRO_0000180237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiP63450.

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1098.

Structurei

3D structure databases

ProteinModelPortaliP63450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105J3Q. Bacteria.
COG0236. LUCA.
HOGENOMiHOG000178184.
OMAiATEEYFV.
OrthoDBiEOG6MWNJM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTFDKVAD IIAETSEIDR DTITPESHTI DDLGIDSLDF LDIVFAIDKA
60 70 80 90
FGIKIPLEQW TQEVNEGKVP TEEYFVLKNL CAKIDELVAA KKG
Length:93
Mass (Da):10,361
Last modified:October 11, 2004 - v1
Checksum:i3383710AADA51807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52292.1.
PIRiAI3390.
RefSeqiWP_002963985.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52292; AAL52292; BMEI1111.
GeneIDi3787556.
KEGGibme:BMEI1111.
PATRICi17797802. VBIBruMel146950_0716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52292.1.
PIRiAI3390.
RefSeqiWP_002963985.1. NZ_GG703778.1.

3D structure databases

ProteinModelPortaliP63450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_1098.

Proteomic databases

PRIDEiP63450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52292; AAL52292; BMEI1111.
GeneIDi3787556.
KEGGibme:BMEI1111.
PATRICi17797802. VBIBruMel146950_0716.

Phylogenomic databases

eggNOGiENOG4105J3Q. Bacteria.
COG0236. LUCA.
HOGENOMiHOG000178184.
OMAiATEEYFV.
OrthoDBiEOG6MWNJM.

Enzyme and pathway databases

UniPathwayiUPA00360.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiACPXL_BRUME
AccessioniPrimary (citable) accession number: P63450
Secondary accession number(s): Q8YGP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.