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Protein

Acyl carrier protein AcpXL

Gene

acpXL

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).By similarity

Pathwayi

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein AcpXL
Gene namesi
Name:acpXL
Ordered Locus Names:BMEI1111
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Acyl carrier protein AcpXLPRO_0000180237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiP63450.

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1111.

Structurei

3D structure databases

ProteinModelPortaliP63450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000178184.
OMAiATEEYFV.
OrthoDBiEOG6MWNJM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTFDKVAD IIAETSEIDR DTITPESHTI DDLGIDSLDF LDIVFAIDKA
60 70 80 90
FGIKIPLEQW TQEVNEGKVP TEEYFVLKNL CAKIDELVAA KKG
Length:93
Mass (Da):10,361
Last modified:October 11, 2004 - v1
Checksum:i3383710AADA51807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52292.1.
PIRiAI3390.
RefSeqiNP_540028.1. NC_003317.1.
WP_002963985.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52292; AAL52292; BMEI1111.
GeneIDi3787556.
KEGGibme:BMEI1111.
PATRICi17797802. VBIBruMel146950_0716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52292.1.
PIRiAI3390.
RefSeqiNP_540028.1. NC_003317.1.
WP_002963985.1. NZ_GG703778.1.

3D structure databases

ProteinModelPortaliP63450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI1111.

Proteomic databases

PRIDEiP63450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52292; AAL52292; BMEI1111.
GeneIDi3787556.
KEGGibme:BMEI1111.
PATRICi17797802. VBIBruMel146950_0716.

Phylogenomic databases

HOGENOMiHOG000178184.
OMAiATEEYFV.
OrthoDBiEOG6MWNJM.

Enzyme and pathway databases

UniPathwayiUPA00360.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiACPXL_BRUME
AccessioniPrimary (citable) accession number: P63450
Secondary accession number(s): Q8YGP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 27, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.