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P63427 (ACDP_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable acyl-CoA dehydrogenase fadE25
EC=1.3.99.-
Gene names
Name:fadE25
Synonyms:acd
Ordered Locus Names:Rv3274c, MT3374
ORF Names:MTCY71.14c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactor

FAD By similarity.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytosol

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Probable acyl-CoA dehydrogenase fadE25
PRO_0000201188

Sequences

Sequence LengthMass (Da)Tools
P63427 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2E77D0F28A9C8E08

FASTA38941,723
        10         20         30         40         50         60 
MVGWAGNPSF DLFKLPEEHD EMRSAIRALA EKEIAPHAAE VDEKARFPEE ALVALNSSGF 

        70         80         90        100        110        120 
NAVHIPEEYG GQGADSVATC IVIEEVARVD ASASLIPAVN KLGTMGLILR GSEELKKQVL 

       130        140        150        160        170        180 
PALAAEGAMA SYALSEREAG SDAASMRTRA KADGDHWILN GAKCWITNGG KSTWYTVMAV 

       190        200        210        220        230        240 
TDPDRGANGI SAFMVHKDDE GFTVGPKERK LGIKGSPTTE LYFENCRIPG DRIIGEPGTG 

       250        260        270        280        290        300 
FKTALATLDH TRPTIGAQAV GIAQGALDAA IAYTKDRKQF GESISTFQAV QFMLADMAMK 

       310        320        330        340        350        360 
VEAARLMVYS AAARAERGEP DLGFISAASK CFASDVAMEV TTDAVQLFGG AGYTTDFPVE 

       370        380 
RFMRDAKITQ IYEGTNQIQR VVMSRALLR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAB07077.1.
AE000516 Genomic DNA. Translation: AAK47715.1.
PIRC70979.
RefSeqNP_217791.1. NC_000962.2.
NP_337901.1. NC_002755.2.

3D structure databases

ProteinModelPortalP63427.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000383; EBMYCP00000000383; EBMYCG00000000383.
EBMYCT00000071549; EBMYCP00000069608; EBMYCG00000071544.
GeneID888731.
922449.
GenomeReviewsGene locus MT3374 in contig AE000516_GR.
Gene locus Rv3274c in contig AL123456_GR.
KEGGmtc:MT3374.
mtu:Rv3274c.
PATRIC18129170. VBIMycTub22151_3681.
TIGRMT3374.

Organism-specific databases

TubercuListRv3274c.

Phylogenomic databases

GeneTreeEBGT00050000015288.
HOGENOMHBG699365.
OMADENARFP.
PhylomeDBP63427.
ProtClustDBCLSK872163.

Family and domain databases

InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
KOK00257.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMSSF56645. AcylCoA_dehyd_NM. 1 hit.
SSF47203. AcylCoADH_C_like. 1 hit.
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACDP_MYCTU
AccessionPrimary (citable) accession number: P63427
Secondary accession number(s): P96879
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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