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Protein

Probable propionyl-CoA carboxylase beta chain 6

Gene

accD6

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 6 (accD6)
  2. no protein annotated in this organism
  3. Probable methylmalonyl-CoA mutase large subunit (mutB), Probable methylmalonyl-CoA mutase small subunit (mutA)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 6 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD6
Ordered Locus Names:BQ2027_MB2271
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998011 – 473Probable propionyl-CoA carboxylase beta chain 6Add BLAST473

Proteomic databases

PRIDEiP63408.

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63408.
SMRiP63408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 224CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST224
Domaini225 – 473CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 473CarboxyltransferasePROSITE-ProRule annotationAdd BLAST473

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

HOGENOMiHOG000218693.
KOiK18472.
OMAiAMGVDGC.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P63408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIMAPEAVG ESLDPRDPLL RLSNFFDDGS VELLHERDRS GVLAAAGTVN
60 70 80 90 100
GVRTIAFCTD GTVMGGAMGV EGCTHIVNAY DTAIEDQSPI VGIWHSGGAR
110 120 130 140 150
LAEGVRALHA VGQVFEAMIR ASGYIPQISV VVGFAAGGAA YGPALTDVVV
160 170 180 190 200
MAPESRVFVT GPDVVRSVTG EDVDMASLGG PETHHKKSGV CHIVADDELD
210 220 230 240 250
AYDRGRRLVG LFCQQGHFDR SKAEAGDTDI HALLPESSRR AYDVRPIVTA
260 270 280 290 300
ILDADTPFDE FQANWAPSMV VGLGRLSGRT VGVLANNPLR LGGCLNSESA
310 320 330 340 350
EKAARFVRLC DAFGIPLVVV VDVPGYLPGV DQEWGGVVRR GAKLLHAFGE
360 370 380 390 400
CTVPRVTLVT RKTYGGAYIA MNSRSLNATK VFAWPDAEVA VMGAKAAVGI
410 420 430 440 450
LHKKKLAAAP EHEREALHDQ LAAEHERIAG GVDSALDIGV VDEKIDPAHT
460 470
RSKLTEALAQ APARRGRHKN IPL
Length:473
Mass (Da):50,136
Last modified:October 11, 2004 - v1
Checksum:i94AD7EBD88F233C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU00882.1.
RefSeqiNP_855920.1. NC_002945.3.
WP_003900487.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO43528; CDO43528; Mb2271.
KEGGimbo:Mb2271.
PATRICifig|233413.5.peg.2492.

Similar proteinsi

Entry informationi

Entry nameiPCC6_MYCBO
AccessioniPrimary (citable) accession number: P63408
Secondary accession number(s): A0A1R3Y0N7, Q10506, X2BKK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families