P63389 (YHES_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized ABC transporter ATP-binding protein YheS

Gene names

Name:	yheS
Ordered Locus Names:	b3352, JW3315

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
tufA	P0CE47	2	EBI-561198,EBI-301077

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	Uncharacterized ABC transporter ATP-binding protein YheS		PRO_0000093187
Regions
	Domain	2 – 246	245	ABC transporter 1
	Domain	313 – 527	215	ABC transporter 2
	Nucleotide binding	34 – 41	8	ATP 1 Potential
	Nucleotide binding	345 – 352	8	ATP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	P63389 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 81BC859FC1105EC5	FASTA	637	71,843
	10 20 30 40 50 60 MIVFSSLQIR RGVRVLLDNA TATINPGQKV GLVGKNGCGK STLLALLKNE ISADGGSYTF 70 80 90 100 110 120 PGSWQLAWVN QETPALPQAA LEYVIDGDRE YRQLEAQLHD ANERNDGHAI ATIHGKLDAI 130 140 150 160 170 180 DAWSIRSRAA SLLHGLGFSN EQLERPVSDF SGGWRMRLNL AQALICRSDL LLLDEPTNHL 190 200 210 220 230 240 DLDAVIWLEK WLKSYQGTLI LISHDRDFLD PIVDKIIHIE QQSMFEYTGN YSSFEVQRAT 250 260 270 280 290 300 RLAQQQAMYE SQQERVAHLQ SYIDRFRAKA TKAKQAQSRI KMLERMELIA PAHVDNPFRF 310 320 330 340 350 360 SFRAPESLPN PLLKMEKVSA GYGDRIILDS IKLNLVPGSR IGLLGRNGAG KSTLIKLLAG 370 380 390 400 410 420 ELAPVSGEIG LAKGIKLGYF AQHQLEYLRA DESPIQHLAR LAPQELEQKL RDYLGGFGFQ 430 440 450 460 470 480 GDKVTEETRR FSGGEKARLV LALIVWQRPN LLLLDEPTNH LDLDMRQALT EALIEFEGAL 490 500 510 520 530 540 VVVSHDRHLL RSTTDDLYLV HDRKVEPFDG DLEDYQQWLS DVQKQENQTD EAPKENANSA 550 560 570 580 590 600 QARKDQKRRE AELRAQTQPL RKEIARLEKE MEKLNAQLAQ AEEKLGDSEL YDQSRKAELT 610 620 630 ACLQQQASAK SGLEECEMAW LEAQEQLEQM LLEGQSN

References

[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18997 Genomic DNA. Translation: AAA58149.1. U00096 Genomic DNA. Translation: AAC76377.1. AP009048 Genomic DNA. Translation: BAE77938.1.
PIR	C65129.
RefSeq	NP_417811.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P63389.
SMR	P63389. Positions 1-518.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48200N.
IntAct	P63389. 5 interactions.
MINT	MINT-1274432.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001435; EBESCP00000001435; EBESCG00000001197. EBESCT00000015922; EBESCP00000015213; EBESCG00000014982.
GeneID	947856.
GenomeReviews	Gene locus JW3315 in contig AP009048_GR. Gene locus b3352 in contig U00096_GR.
KEGG	ecj:JW3315. eco:b3352.
PATRIC	32122138. VBIEscCol129921_3446.
Organism-specific databases
EchoBASE	EB2740.
EcoGene	EG12903. yheS.
Phylogenomic databases
eggNOG	COG0488.
GeneTree	EBGT00050000008245.
HOGENOM	HBG758042.
OMA	SCSDYYL.
PhylomeDB	P63389.
ProtClustDB	PRK10636.
Enzyme and pathway databases
BioCyc	EcoCyc:YHES-MONOMER.
Gene expression databases
Genevestigator	P63389.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K06158.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YHES_ECOLI

Accession

Primary (citable) accession number: P63389
Secondary accession number(s): P45535, Q2M718

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program