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P63359 (MSBA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipid A export ATP-binding/permease protein MsbA
EC=3.6.3.-
Gene names
Name:msbA
Ordered Locus Names:STM0984
OrganismSalmonella typhimurium
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity. HAMAP MF_01703

Subunit structure

Homodimer By similarity. HAMAP MF_01703

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01703.

Domain

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. HAMAP MF_01703

Sequence similarities

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Lipid A export ATP-binding/permease protein MsbA HAMAP MF_01703
PRO_0000092598

Regions

Transmembrane64 – 8421Helical; Potential
Transmembrane140 – 16223Helical; Potential
Transmembrane167 – 18620Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane275 – 29521Helical; Potential
Domain27 – 310284ABC transmembrane type-1
Domain342 – 578237ABC transporter
Nucleotide binding376 – 3838ATP By similarity

Secondary structure

1 .......................................................................... 582
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P63359 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A8806F8CC650D538

FASTA58264,340
        10         20         30         40         50         60 
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GIALILNAAS DTFMLSLLKP LLDDGFGKTD 

        70         80         90        100        110        120 
RSVLLWMPLV VIGLMILRGI TSYISSYCIS WVSGKVVMTM RRRLFGHMMG MPVAFFDKQS 

       130        140        150        160        170        180 
TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LVVLAPIVSI 

       190        200        210        220        230        240 
AIRVVSKRFR SISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNKMRLQ 

       250        260        270        280        290        300 
GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS 

       310        320        330        340        350        360 
LTNVNAQFQR GMAACQTLFA ILDSEQEKDE GKRVIDRATG DLEFRNVTFT YPGREVPALR 

       370        380        390        400        410        420 
NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGHI LMDGHDLREY TLASLRNQVA 

       430        440        450        460        470        480 
LVSQNVHLFN DTVANNIAYA RTEEYSREQI EEAARMAYAM DFINKMDNGL DTIIGENGVL 

       490        500        510        520        530        540 
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS 

       550        560        570        580 
TIEQADEIVV VEDGIIVERG THSELLAQHG VYAQLHKMQF GQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006468 Genomic DNA. Translation: AAL19918.1.
RefSeqNP_459959.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5YX-ray4.50A/B/C/D1-582[»]
3B5ZX-ray4.20A/B/C/D1-582[»]
3B60X-ray3.70A/B/C/D1-582[»]
ProteinModelPortalP63359.
SMRP63359. Positions 10-581.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-46177N.

Proteomic databases

PRIDEP63359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1252502.
GenomeReviewsGene locus STM0984 in contig AE006468_GR.
KEGGstm:STM0984.
PATRIC32380381. VBISalEnt20916_1037.

Phylogenomic databases

HOGENOMHBG758042.
OMANHTELLE.
ProtClustDBPRK11176.

Enzyme and pathway databases

BioCycSTYP99287:STM0984-MONOMER.

Family and domain databases

HAMAPMF_01703. ABC_ATPase_TM_MsbA.
[Tree]
InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR011917. ABC_transpr_lipidA.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
KOK11085.
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 1 hit.
TIGRFAMsTIGR02203. MsbA_lipidA. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSBA_SALTY
AccessionPrimary (citable) accession number: P63359
Secondary accession number(s): Q8XFG5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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