P63338 (6PGL_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	Rv1445c, MT1492
ORF Names:	MTCY493.09

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 247

247

6-phosphogluconolactonase

PRO_0000090101

Secondary structure

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247

Helix Strand Turn

Details...

Beta strand

4 – 10

7

Helix

11 – 17

7

Helix

29 – 32

4

Beta strand

36 – 39

4

Helix

48 – 56

9

Helix

57 – 59

3

Helix

62 – 64

3

Beta strand

65 – 68

4

Helix

83 – 90

8

Helix

92 – 94

3

Helix

99 – 101

3

Helix

116 – 130

15

Beta strand

141 – 145

5

Helix

161 – 164

4

Beta strand

169 – 174

6

Beta strand

177 – 181

5

Beta strand

183 – 186

4

Helix

188 – 191

4

Beta strand

194 – 201

8

Helix

207 – 213

7

Turn

219 – 221

3

Beta strand

232 – 239

8

Sequences

	Sequence		Length	Mass (Da)
	P63338 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 1639B68A595D7D2C	FASTA	247	25,804
	10 20 30 40 50 60 MSSSIEIFPD SDILVAAAGK RLVGAIGAAV AARGQALIVL TGGGNGIALL RYLSAQAQQI 70 80 90 100 110 120 EWSKVHLFWG DERYVPEDDD ERNLKQARRA LLNHVDIPSN QVHPMAASDG DFGGDLDAAA 130 140 150 160 170 180 LAYEQVLAAS AAPGDPAPNF DVHLLGMGPE GHINSLFPHS PAVLESTRMV VAVDDSPKPP 190 200 210 220 230 240 PRRITLTLPA IQRSREVWLL VSGPGKADAV AAAIGGADPV SVPAAGAVGR QNTLWLLDRD AAAKLPS

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX842576 Genomic DNA. Translation: CAB09261.1.
AE000516 Genomic DNA. Translation: AAK45755.1.

PIR

H70916.

RefSeq

NP_215961.1. NC_000962.2.
NP_335941.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ICO	X-ray	2.15	A/B/C/D	1-247	[»]

ProteinModelPortal

P63338.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000002526; EBMYCP00000002526; EBMYCG00000002524.
EBMYCT00000072149; EBMYCP00000070208; EBMYCG00000072144.

GeneID

886617.
924478.

GenomeReviews

Gene locus MT1492 in contig AE000516_GR.
Gene locus Rv1445c in contig AL123456_GR.

KEGG

mtc:MT1492.
mtu:Rv1445c.

PATRIC

18125046. VBIMycTub22151_1638.

TIGR

MT1492.

Organism-specific databases

TubercuList

Rv1445c.

Phylogenomic databases

GeneTree

EBGT00050000017647.

HOGENOM

HBG725991.

OMA

APFNSEI.

PhylomeDB

P63338.

ProtClustDB

CLSK791167.

Family and domain databases

InterPro

IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]

KO

K01057.

Pfam

PF01182. Glucosamine_iso. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01198. Pgl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

6PGL_MYCTU

Accession

Primary (citable) accession number: P63338
Secondary accession number(s): O06814

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program