Reviewed, UniProtKB/Swiss-Prot P63338 (6PGL_MYCTU)

Names and origin

Protein names

Recommended name:
    6-phosphogluconolactonase
      Short name=6PGL
    EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	Rv1445c, MT1492
ORF Names:	MTCY493.09

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	6-phosphogluconolactonase		PRO_0000090101

Sequences

	Sequence		Length	Mass (Da)
	P63338-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 1639B68A595D7D2C	FASTA	247	25,804
	10 20 30 40 50 60 MSSSIEIFPD SDILVAAAGK RLVGAIGAAV AARGQALIVL TGGGNGIALL RYLSAQAQQI 70 80 90 100 110 120 EWSKVHLFWG DERYVPEDDD ERNLKQARRA LLNHVDIPSN QVHPMAASDG DFGGDLDAAA 130 140 150 160 170 180 LAYEQVLAAS AAPGDPAPNF DVHLLGMGPE GHINSLFPHS PAVLESTRMV VAVDDSPKPP 190 200 210 220 230 240 PRRITLTLPA IQRSREVWLL VSGPGKADAV AAAIGGADPV SVPAAGAVGR QNTLWLLDRD AAAKLPS

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases

EMBLGenBankDDBJ

BX842576 Genomic DNA. Translation: CAB09261.1.
AE000516 Genomic DNA. Translation: AAK45755.1.

PIR

H70916.

RefSeq

NP_215961.1.
NP_335941.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ICO	X-ray	2.15	A/B/C/D	1-247	[»]

ModBase

Search...

Genome annotation databases

GeneID

886617.
924478.

GenomeReviews

Gene locus MT1492 in contig AE000516_GR.
Gene locus Rv1445c in contig AL123456_GR.

KEGG

mtc:MT1492.
mtu:Rv1445c.

TIGR

MT1492.

Organism-specific databases

TubercuList

Rv1445c.

Phylogenomic databases

HOGENOM

P63338.

OMA

PAICLTG.

Enzyme and pathway databases

BRENDA

3.1.1.31. 809.

Family and domain databases

InterPro

IPR005900. 6-phosphogluconolactonase.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]

PANTHER

PTHR11054. Phosphogluconlac. 1 hit.

Pfam

PF01182. Glucosamine_iso. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01198. pgl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

6PGL_MYCTU

Accession

Primary (citable) accession number: P63338
Secondary accession number(s): O06814

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)