Reviewed, UniProtKB/Swiss-Prot P63336 (6PGL_NEIMA)

Names and origin

Protein names

Recommended name:
    6-phosphogluconolactonase
      Short name=6PGL
    EC=3.1.1.31

Gene names

Name:	pgl
Ordered Locus Names:	NMA1608

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	6-phosphogluconolactonase		PRO_0000090097

Sequences

	Sequence		Length	Mass (Da)
	P63336-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5EF54C495553D073	FASTA	231	24,980
	10 20 30 40 50 60 MFVWHEYENA AEAAQSLADA VADALQGALD EKGGAVLAVS GGRSPIAFFN ALSQKDLDWK 70 80 90 100 110 120 NVGITLADER IVPTVHADSN TGLVREYLLK NKAEAAMWIP MVEDGKTETE LHPDAVVDYA 130 140 150 160 170 180 LKHYKQPDVL VLGMGNDGHT ASIFPKAPQF QTAIDGSAGV ALVHTTPVTA PHERVSMTLD 190 200 210 220 230 AIAHTGHVFL AIRGEEKKAV FDQAAQGENR EYPINLVLNH QGVNCHVFYA E

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL157959 Genomic DNA. Translation: CAM08748.1.
RefSeq	YP_002342918.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	907997.
GenomeReviews	Gene locus NMA1608 in contig AL157959_GR.
KEGG	nma:NMA1608.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P63336.
OMA	LYQPAAS.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA1608-MON.
BRENDA	3.1.1.31. 292829.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase. [Graphical view]
PANTHER	PTHR11054. Phosphogluconlac. 1 hit.
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_NEIMA

Accession

Primary (citable) accession number: P63336
Secondary accession number(s): A1ISJ0, Q9JR64

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)