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P63334

- 6PGD_STAAN

UniProt

P63334 - 6PGD_STAAN

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011NADPBy similarity
    Binding sitei101 – 1011SubstrateBy similarity
    Active sitei182 – 1821Proton acceptorBy similarity
    Active sitei189 – 1891Proton donorBy similarity
    Binding sitei190 – 1901SubstrateBy similarity
    Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Binding sitei444 – 4441Substrate; shared with dimeric partnerBy similarity
    Binding sitei450 – 4501Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPBy similarity
    Nucleotide bindingi32 – 343NADPBy similarity
    Nucleotide bindingi73 – 753NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-1411-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:SA1342
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090053Add
    BLAST

    2D gel databases

    SWISS-2DPAGEP63334.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi158879.SA1342.

    Structurei

    3D structure databases

    ProteinModelPortaliP63334.
    SMRiP63334. Positions 3-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Substrate bindingBy similarity
    Regioni185 – 1862Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63334-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQQIGVIGL AVMGKNLAWN IESRGYSVSV FNRSSEKTDL MVEESKGKNI    50
    HPTYSLEEFV NSLEKPRKIL LMVQAGKATD ATIDSLLPLL DDGDILIDGG 100
    NTNYQDTIRR NKALAQSAIN FIGMGVSGGE IGALTGPSLM PGGQEEAYNK 150
    VADILDAIAA KAKDGASCVT YIGPNGAGHY VKMVHNGIEY ADMQLIAESY 200
    AMMKELLGMS HEDIAQTFKD WNAGELESYL IEITGDIFMK LDENKEALVE 250
    KILDTAGQKG TGKWTSINAL ELGIPLTIIT ESVFARFISS IKEERVNASK 300
    ELNGPKASFD GDKKDFLEKI RKALYMSKIC SYAQGFAQMR KASEDNEWNL 350
    KLGDLAMIWR EGCIIRAQFL QKIKDAYDNN PGLQNLLLDP YFKNIVTEYQ 400
    DALRDVVATG VQNGVPTPGF SSSINYYDSY RAADLPANLI QAQRDYFGAH 450
    TYERKDKEGV FHTQWIEE 468
    Length:468
    Mass (Da):51,803
    Last modified:October 11, 2004 - v1
    Checksum:i61A5C2CAF3CCD011
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42604.1.
    PIRiG89930.
    RefSeqiNP_374625.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB42604; BAB42604; BAB42604.
    GeneIDi1124182.
    KEGGisau:SA1342.
    PATRICi19574952. VBIStaAur116463_1445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42604.1 .
    PIRi G89930.
    RefSeqi NP_374625.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali P63334.
    SMRi P63334. Positions 3-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA1342.

    2D gel databases

    SWISS-2DPAGE P63334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB42604 ; BAB42604 ; BAB42604 .
    GeneIDi 1124182.
    KEGGi sau:SA1342.
    PATRICi 19574952. VBIStaAur116463_1445.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SAUR158879:GJCB-1411-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: N315.
    3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry namei6PGD_STAAN
    AccessioniPrimary (citable) accession number: P63334
    Secondary accession number(s): Q99TY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3