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Protein

40S ribosomal protein S10

Gene

Rps10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the 40S ribosomal subunit.By similarity

GO - Molecular functioni

  • structural constituent of ribosome Source: RGD
  • tRNA binding Source: RGD

GO - Biological processi

  • ribosomal small subunit assembly Source: RGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72649 Translation initiation complex formation
R-RNO-72689 Formation of a pool of free 40S subunits
R-RNO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-RNO-72702 Ribosomal scanning and start codon recognition
R-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10
Gene namesi
Name:Rps10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621024 Rps10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163621 – 16540S ribosomal protein S10Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphotyrosineBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei146PhosphoserineBy similarity1
Modified residuei153Omega-N-methylarginineBy similarity1
Modified residuei158Symmetric dimethylarginineBy similarity1
Modified residuei160Symmetric dimethylarginineBy similarity1

Post-translational modificationi

Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation (By similarity).By similarity
Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP63326
PRIDEiP63326

PTM databases

iPTMnetiP63326
PhosphoSitePlusiP63326

Expressioni

Gene expression databases

BgeeiENSRNOG00000052141
GenevisibleiP63326 RN

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249645, 2 interactors
IntActiP63326, 2 interactors
MINTiP63326
STRINGi10116.ENSRNOP00000061642

Structurei

3D structure databases

ProteinModelPortaliP63326
SMRiP63326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3344 Eukaryota
COG5045 LUCA
GeneTreeiENSGT00440000034918
HOGENOMiHOG000216624
HOVERGENiHBG001253
InParanoidiP63326
KOiK02947
OMAiQMLMPKK
OrthoDBiEOG091G0QTW
PhylomeDBiP63326
TreeFamiTF319100

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037447 Rps10
IPR005326 S10_plectin_N
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12146 PTHR12146, 1 hit
PfamiView protein in Pfam
PF03501 S10_plectin, 1 hit

Sequencei

Sequence statusi: Complete.

P63326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ
60 70 80 90 100
SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE
110 120 130 140 150
TGRPRPKGPE GERPARFTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF
160
QFRGGFGRGR GQPPQ
Length:165
Mass (Da):18,916
Last modified:October 11, 2004 - v1
Checksum:i75B7005BA57AABA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13549 mRNA Translation: CAA31901.1
BC058141 mRNA Translation: AAH58141.1
PIRiS01881 R3RT10
RefSeqiNP_112371.1, NM_031109.2
XP_002729669.1, XM_002729623.2
XP_003754221.1, XM_003754173.2
UniGeneiRn.3359

Genome annotation databases

EnsembliENSRNOT00000043250; ENSRNOP00000043693; ENSRNOG00000052141
GeneIDi100363439
81773
KEGGirno:100363439
rno:81773
UCSCiRGD:621024 rat

Similar proteinsi

Entry informationi

Entry nameiRS10_RAT
AccessioniPrimary (citable) accession number: P63326
Secondary accession number(s): P09900, Q9DCR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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