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Protein

40S ribosomal protein S10

Gene

Rps10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the 40S ribosomal subunit.By similarity

GO - Molecular functioni

  • structural constituent of ribosome Source: RGD
  • tRNA binding Source: RGD

GO - Biological processi

  • ribosomal small subunit assembly Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10
Gene namesi
Name:Rps10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621024. Rps10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus (By similarity).By similarity

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16516540S ribosomal protein S10PRO_0000116362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphotyrosineBy similarity
Modified residuei146 – 1461PhosphoserineBy similarity
Modified residuei158 – 1581Symmetric dimethylarginineBy similarity
Modified residuei160 – 1601Symmetric dimethylarginineBy similarity

Post-translational modificationi

Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP63326.
PRIDEiP63326.

PTM databases

iPTMnetiP63326.
PhosphoSiteiP63326.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000490.
GenevisibleiP63326. RN.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249645. 2 interactions.
IntActiP63326. 2 interactions.
MINTiMINT-1857314.
STRINGi10116.ENSRNOP00000061642.

Structurei

3D structure databases

ProteinModelPortaliP63326.
SMRiP63326. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S10e family.Curated

Phylogenomic databases

eggNOGiKOG3344. Eukaryota.
COG5045. LUCA.
GeneTreeiENSGT00440000034918.
HOGENOMiHOG000216624.
HOVERGENiHBG001253.
InParanoidiP63326.
KOiK02947.
OMAiLQMLMPK.
OrthoDBiEOG091G0QTW.
PhylomeDBiP63326.
TreeFamiTF319100.

Family and domain databases

InterProiIPR005326. S10_plectin_N.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ
60 70 80 90 100
SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE
110 120 130 140 150
TGRPRPKGPE GERPARFTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF
160
QFRGGFGRGR GQPPQ
Length:165
Mass (Da):18,916
Last modified:October 11, 2004 - v1
Checksum:i75B7005BA57AABA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13549 mRNA. Translation: CAA31901.1.
BC058141 mRNA. Translation: AAH58141.1.
PIRiS01881. R3RT10.
RefSeqiNP_112371.1. NM_031109.1.
XP_002729669.1. XM_002729623.2.
XP_003754221.1. XM_003754173.2.
UniGeneiRn.3359.

Genome annotation databases

EnsembliENSRNOT00000043250; ENSRNOP00000043693; ENSRNOG00000052141.
GeneIDi100363439.
81773.
KEGGirno:100363439.
rno:81773.
UCSCiRGD:621024. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13549 mRNA. Translation: CAA31901.1.
BC058141 mRNA. Translation: AAH58141.1.
PIRiS01881. R3RT10.
RefSeqiNP_112371.1. NM_031109.1.
XP_002729669.1. XM_002729623.2.
XP_003754221.1. XM_003754173.2.
UniGeneiRn.3359.

3D structure databases

ProteinModelPortaliP63326.
SMRiP63326. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249645. 2 interactions.
IntActiP63326. 2 interactions.
MINTiMINT-1857314.
STRINGi10116.ENSRNOP00000061642.

PTM databases

iPTMnetiP63326.
PhosphoSiteiP63326.

Proteomic databases

PaxDbiP63326.
PRIDEiP63326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043250; ENSRNOP00000043693; ENSRNOG00000052141.
GeneIDi100363439.
81773.
KEGGirno:100363439.
rno:81773.
UCSCiRGD:621024. rat.

Organism-specific databases

CTDi100363439.
6204.
RGDi621024. Rps10.

Phylogenomic databases

eggNOGiKOG3344. Eukaryota.
COG5045. LUCA.
GeneTreeiENSGT00440000034918.
HOGENOMiHOG000216624.
HOVERGENiHBG001253.
InParanoidiP63326.
KOiK02947.
OMAiLQMLMPK.
OrthoDBiEOG091G0QTW.
PhylomeDBiP63326.
TreeFamiTF319100.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP63326.

Gene expression databases

BgeeiENSRNOG00000000490.
GenevisibleiP63326. RN.

Family and domain databases

InterProiIPR005326. S10_plectin_N.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS10_RAT
AccessioniPrimary (citable) accession number: P63326
Secondary accession number(s): P09900, Q9DCR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.