Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S10

Gene

Rps10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 40S ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10
Gene namesi
Name:Rps10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914347. Rps10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163611 – 16540S ribosomal protein S10Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphotyrosineCombined sources1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei146PhosphoserineCombined sources1
Modified residuei153Omega-N-methylarginineCombined sources1
Modified residuei158Symmetric dimethylarginineBy similarity1
Modified residuei160Symmetric dimethylarginineBy similarity1

Post-translational modificationi

Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation (By similarity).By similarity
Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP63325.
PaxDbiP63325.
PeptideAtlasiP63325.
PRIDEiP63325.
TopDownProteomicsiP63325.

PTM databases

iPTMnetiP63325.
PhosphoSitePlusiP63325.
SwissPalmiP63325.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052146.
CleanExiMM_RPS10.
ExpressionAtlasiP63325. baseline and differential.
GenevisibleiP63325. MM.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211937. 3 interactors.
IntActiP63325. 3 interactors.
MINTiMINT-1857301.
STRINGi10090.ENSMUSP00000110531.

Structurei

3D structure databases

ProteinModelPortaliP63325.
SMRiP63325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3344. Eukaryota.
COG5045. LUCA.
GeneTreeiENSGT00440000034918.
HOGENOMiHOG000216624.
HOVERGENiHBG001253.
InParanoidiP63325.
KOiK02947.
OMAiQMLMPKK.
OrthoDBiEOG091G0QTW.
PhylomeDBiP63325.
TreeFamiTF319100.

Family and domain databases

InterProiView protein in InterPro
IPR005326. S10_plectin_N.
PfamiView protein in Pfam
PF03501. S10_plectin. 1 hit.

Sequencei

Sequence statusi: Complete.

P63325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ
60 70 80 90 100
SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE
110 120 130 140 150
TGRPRPKGPE GERPARFTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF
160
QFRGGFGRGR GQPPQ
Length:165
Mass (Da):18,916
Last modified:October 11, 2004 - v1
Checksum:i75B7005BA57AABA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008797 mRNA. Translation: BAB25901.1.
AK011065 mRNA. Translation: BAB27372.1.
AK002558 mRNA. No translation available.
BC003853 mRNA. Translation: AAH03853.1.
BC019725 mRNA. Translation: AAH19725.1.
CCDSiCCDS37522.1.
PIRiH59404.
RefSeqiNP_080239.1. NM_025963.3.
UniGeneiMm.275810.
Mm.383217.

Genome annotation databases

EnsembliENSMUST00000114881; ENSMUSP00000110531; ENSMUSG00000052146.
ENSMUST00000114882; ENSMUSP00000110532; ENSMUSG00000052146.
ENSMUST00000178774; ENSMUSP00000136042; ENSMUSG00000052146.
GeneIDi67097.
KEGGimmu:67097.
UCSCiuc008bph.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRS10_MOUSE
AccessioniPrimary (citable) accession number: P63325
Secondary accession number(s): P09900, Q9DCR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families