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P63325

- RS10_MOUSE

UniProt

P63325 - RS10_MOUSE

Protein

40S ribosomal protein S10

Gene

Rps10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the 40S ribosomal subunit.By similarity

    GO - Molecular functioni

    1. structural constituent of ribosome Source: Ensembl

    GO - Biological processi

    1. ribosomal small subunit assembly Source: Ensembl

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S10
    Gene namesi
    Name:Rps10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1914347. Rps10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleolus By similarity
    Note: Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus By similarity.By similarity

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: Ensembl
    2. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16516540S ribosomal protein S10PRO_0000116361Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphotyrosine1 Publication
    Modified residuei146 – 1461Phosphoserine1 Publication
    Modified residuei158 – 1581Symmetric dimethylarginineBy similarity
    Modified residuei160 – 1601Symmetric dimethylarginineBy similarity

    Post-translational modificationi

    Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation By similarity.By similarity

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP63325.
    PaxDbiP63325.
    PRIDEiP63325.

    PTM databases

    PhosphoSiteiP63325.

    Expressioni

    Gene expression databases

    BgeeiP63325.
    CleanExiMM_RPS10.
    GenevestigatoriP63325.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211937. 3 interactions.
    IntActiP63325. 3 interactions.
    MINTiMINT-1857301.

    Structurei

    3D structure databases

    ProteinModelPortaliP63325.
    SMRiP63325. Positions 1-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S10e family.Curated

    Phylogenomic databases

    eggNOGiCOG5045.
    HOGENOMiHOG000216624.
    HOVERGENiHBG001253.
    InParanoidiP63325.
    KOiK02947.
    OMAiQMLMPKK.
    OrthoDBiEOG7VB2H1.
    PhylomeDBiP63325.
    TreeFamiTF319100.

    Family and domain databases

    InterProiIPR005326. S10_plectin_N.
    [Graphical view]
    PfamiPF03501. S10_plectin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63325-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ    50
    SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE 100
    TGRPRPKGPE GERPARFTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF 150
    QFRGGFGRGR GQPPQ 165
    Length:165
    Mass (Da):18,916
    Last modified:October 11, 2004 - v1
    Checksum:i75B7005BA57AABA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008797 mRNA. Translation: BAB25901.1.
    AK011065 mRNA. Translation: BAB27372.1.
    AK002558 mRNA. No translation available.
    BC003853 mRNA. Translation: AAH03853.1.
    BC019725 mRNA. Translation: AAH19725.1.
    CCDSiCCDS37522.1.
    PIRiH59404.
    RefSeqiNP_080239.1. NM_025963.3.
    UniGeneiMm.275810.
    Mm.383217.

    Genome annotation databases

    EnsembliENSMUST00000114881; ENSMUSP00000110531; ENSMUSG00000052146.
    ENSMUST00000114882; ENSMUSP00000110532; ENSMUSG00000052146.
    ENSMUST00000178774; ENSMUSP00000136042; ENSMUSG00000052146.
    GeneIDi67097.
    KEGGimmu:67097.
    UCSCiuc008bph.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008797 mRNA. Translation: BAB25901.1 .
    AK011065 mRNA. Translation: BAB27372.1 .
    AK002558 mRNA. No translation available.
    BC003853 mRNA. Translation: AAH03853.1 .
    BC019725 mRNA. Translation: AAH19725.1 .
    CCDSi CCDS37522.1.
    PIRi H59404.
    RefSeqi NP_080239.1. NM_025963.3.
    UniGenei Mm.275810.
    Mm.383217.

    3D structure databases

    ProteinModelPortali P63325.
    SMRi P63325. Positions 1-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211937. 3 interactions.
    IntActi P63325. 3 interactions.
    MINTi MINT-1857301.

    PTM databases

    PhosphoSitei P63325.

    Proteomic databases

    MaxQBi P63325.
    PaxDbi P63325.
    PRIDEi P63325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114881 ; ENSMUSP00000110531 ; ENSMUSG00000052146 .
    ENSMUST00000114882 ; ENSMUSP00000110532 ; ENSMUSG00000052146 .
    ENSMUST00000178774 ; ENSMUSP00000136042 ; ENSMUSG00000052146 .
    GeneIDi 67097.
    KEGGi mmu:67097.
    UCSCi uc008bph.1. mouse.

    Organism-specific databases

    CTDi 6204.
    MGIi MGI:1914347. Rps10.

    Phylogenomic databases

    eggNOGi COG5045.
    HOGENOMi HOG000216624.
    HOVERGENi HBG001253.
    InParanoidi P63325.
    KOi K02947.
    OMAi QMLMPKK.
    OrthoDBi EOG7VB2H1.
    PhylomeDBi P63325.
    TreeFami TF319100.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 323566.
    PROi P63325.
    SOURCEi Search...

    Gene expression databases

    Bgeei P63325.
    CleanExi MM_RPS10.
    Genevestigatori P63325.

    Family and domain databases

    InterProi IPR005326. S10_plectin_N.
    [Graphical view ]
    Pfami PF03501. S10_plectin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney, Liver and Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiRS10_MOUSE
    AccessioniPrimary (citable) accession number: P63325
    Secondary accession number(s): P09900, Q9DCR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3