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P63325

- RS10_MOUSE

UniProt

P63325 - RS10_MOUSE

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Protein

40S ribosomal protein S10

Gene

Rps10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Component of the 40S ribosomal subunit.By similarity

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10
Gene namesi
Name:Rps10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1914347. Rps10.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleolus By similarity
Note: Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus (By similarity).By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16516540S ribosomal protein S10PRO_0000116361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphotyrosine1 Publication
Modified residuei146 – 1461Phosphoserine1 Publication
Modified residuei158 – 1581Symmetric dimethylarginineBy similarity
Modified residuei160 – 1601Symmetric dimethylarginineBy similarity

Post-translational modificationi

Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP63325.
PaxDbiP63325.
PRIDEiP63325.

PTM databases

PhosphoSiteiP63325.

Expressioni

Gene expression databases

BgeeiP63325.
CleanExiMM_RPS10.
ExpressionAtlasiP63325. baseline and differential.
GenevestigatoriP63325.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211937. 3 interactions.
IntActiP63325. 3 interactions.
MINTiMINT-1857301.

Structurei

3D structure databases

ProteinModelPortaliP63325.
SMRiP63325. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S10e family.Curated

Phylogenomic databases

eggNOGiCOG5045.
HOGENOMiHOG000216624.
HOVERGENiHBG001253.
InParanoidiP63325.
KOiK02947.
OMAiQMLMPKK.
OrthoDBiEOG7VB2H1.
PhylomeDBiP63325.
TreeFamiTF319100.

Family and domain databases

InterProiIPR005326. S10_plectin_N.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63325-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ
60 70 80 90 100
SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE
110 120 130 140 150
TGRPRPKGPE GERPARFTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF
160
QFRGGFGRGR GQPPQ
Length:165
Mass (Da):18,916
Last modified:October 11, 2004 - v1
Checksum:i75B7005BA57AABA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008797 mRNA. Translation: BAB25901.1.
AK011065 mRNA. Translation: BAB27372.1.
AK002558 mRNA. No translation available.
BC003853 mRNA. Translation: AAH03853.1.
BC019725 mRNA. Translation: AAH19725.1.
CCDSiCCDS37522.1.
PIRiH59404.
RefSeqiNP_080239.1. NM_025963.3.
UniGeneiMm.275810.
Mm.383217.

Genome annotation databases

EnsembliENSMUST00000114881; ENSMUSP00000110531; ENSMUSG00000052146.
ENSMUST00000114882; ENSMUSP00000110532; ENSMUSG00000052146.
ENSMUST00000178774; ENSMUSP00000136042; ENSMUSG00000052146.
GeneIDi67097.
KEGGimmu:67097.
UCSCiuc008bph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008797 mRNA. Translation: BAB25901.1 .
AK011065 mRNA. Translation: BAB27372.1 .
AK002558 mRNA. No translation available.
BC003853 mRNA. Translation: AAH03853.1 .
BC019725 mRNA. Translation: AAH19725.1 .
CCDSi CCDS37522.1.
PIRi H59404.
RefSeqi NP_080239.1. NM_025963.3.
UniGenei Mm.275810.
Mm.383217.

3D structure databases

ProteinModelPortali P63325.
SMRi P63325. Positions 1-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211937. 3 interactions.
IntActi P63325. 3 interactions.
MINTi MINT-1857301.

PTM databases

PhosphoSitei P63325.

Proteomic databases

MaxQBi P63325.
PaxDbi P63325.
PRIDEi P63325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114881 ; ENSMUSP00000110531 ; ENSMUSG00000052146 .
ENSMUST00000114882 ; ENSMUSP00000110532 ; ENSMUSG00000052146 .
ENSMUST00000178774 ; ENSMUSP00000136042 ; ENSMUSG00000052146 .
GeneIDi 67097.
KEGGi mmu:67097.
UCSCi uc008bph.1. mouse.

Organism-specific databases

CTDi 6204.
MGIi MGI:1914347. Rps10.

Phylogenomic databases

eggNOGi COG5045.
HOGENOMi HOG000216624.
HOVERGENi HBG001253.
InParanoidi P63325.
KOi K02947.
OMAi QMLMPKK.
OrthoDBi EOG7VB2H1.
PhylomeDBi P63325.
TreeFami TF319100.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi 323566.
PROi P63325.
SOURCEi Search...

Gene expression databases

Bgeei P63325.
CleanExi MM_RPS10.
ExpressionAtlasi P63325. baseline and differential.
Genevestigatori P63325.

Family and domain databases

InterProi IPR005326. S10_plectin_N.
[Graphical view ]
Pfami PF03501. S10_plectin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Liver and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRS10_MOUSE
AccessioniPrimary (citable) accession number: P63325
Secondary accession number(s): P09900, Q9DCR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3