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Protein

40S ribosomal protein S12

Gene

Rps12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • response to organonitrogen compound Source: RGD
  • translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Gene namesi
Name:Rps12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62024. Rps12.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • cytosolic small ribosomal subunit Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 13213140S ribosomal protein S12PRO_0000122326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei129 – 1291N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP63324.
PRIDEiP63324.

PTM databases

iPTMnetiP63324.

Interactioni

Protein-protein interaction databases

IntActiP63324. 2 interactions.
MINTiMINT-2515296.
STRINGi10116.ENSRNOP00000022184.

Structurei

3D structure databases

ProteinModelPortaliP63324.
SMRiP63324. Positions 9-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12e family.Curated

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
InParanoidiP63324.
PhylomeDBiP63324.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC
60 70 80 90 100
VLASNCDEPM YVKLVEALLA EHQINLIKVD DNKKLGEWVG LCKIDREGKP
110 120 130
RKVVGCSCVV VKDYGKESQA KDVIEEYFKC KK
Length:132
Mass (Da):14,525
Last modified:January 23, 2007 - v2
Checksum:i4C3D1BED455FFA2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18547 mRNA. Translation: AAA42077.1. Different termination.
PIRiS13074. R3RT12.
UniGeneiRn.115713.
Rn.8400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18547 mRNA. Translation: AAA42077.1. Different termination.
PIRiS13074. R3RT12.
UniGeneiRn.115713.
Rn.8400.

3D structure databases

ProteinModelPortaliP63324.
SMRiP63324. Positions 9-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63324. 2 interactions.
MINTiMINT-2515296.
STRINGi10116.ENSRNOP00000022184.

PTM databases

iPTMnetiP63324.

Proteomic databases

PaxDbiP63324.
PRIDEiP63324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi62024. Rps12.

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
InParanoidiP63324.
PhylomeDBiP63324.

Miscellaneous databases

PROiP63324.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The primary structure of rat ribosomal protein S12. The relationship of rat S12 to other ribosomal proteins and a correlation of the amino acid sequences of rat and yeast ribosomal proteins."
    Lin A., Chan Y.-L., Jones R., Wool I.G.
    J. Biol. Chem. 262:14343-14351(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-132, ACETYLATION AT ALA-2.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The primary structure of rat ribosomal proteins: the amino acid sequences of L27a and L28 and corrections in the sequences of S4 and S12."
    Wool I.G., Chan Y.-L., Paz V., Olvera J.
    Biochim. Biophys. Acta 1050:69-73(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Bienvenut W.V., von Kriegsheim A.F., Kolch W.
    Submitted (AUG-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-33, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Pheochromocytoma.

Entry informationi

Entry nameiRS12_RAT
AccessioniPrimary (citable) accession number: P63324
Secondary accession number(s): P09388, P12728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.